\u4e00.\u5177\u6297\u6c27\u5316\u529f\u80fd\uff0c\u4ee5\u5ef6\u7de9\u8001\u5316<\/p>\n\n\n\n
\u64da\u7814\u7a76\u6307\u51fa\uff0c\u65e5\u5149\u4e2d\u7684\u7d2b\u5916\u7dda\u662f\u76ae\u819a\u8001\u5316\u7684\u4e3b\u8981\u6bba\u624b\uff0c\u7d2b\u5916\u7dda\u7522\u751f\u7684\u81ea\u7531\u57fa\u80fd\u9020\u6210\u808c\u819a\u4e2d\u7684\u81a0\u539f\u86cb\u767d\u5f48\u529b\u86cb\u767d\u7684\u53d7\u640d\uff0c\u9032\u800c\u4f7f\u76ae\u819a\u7684\u7dca\u5bc6\u5ea6\u8b8a\u5dee\uff0c\u4fdd\u6c34\u6027\u4e5f\u4e0b\u964d\uff0c\u56e0\u6b64\u770b\u8d77\u4f86\u7121\u5149\u6fa4\u800c\u5bb9\u6613\u7522\u751f\u76ba\u7d0b\u3002\u6839\u64da\u7f8e\u570b\u77e5\u540d\u671f\u520a\uff08J. Am. Chem. Soc.\uff09\u65bc1999\u5e74\u767c\u8868\u6587\u737b\u6307\u51fa\uff0c\u8591\u9ec3\u7d20\u672c\u8eab\u4fbf\u53ef\u6c27\u5316\u7dad\u751f\u7d20C\u53ca\u7dad\u751f\u7d20E\uff0c\u8868\u793a\u8591\u9ec3\u7d20\u7684\u6297\u6c27\u5316\u80fd\u529b\u9ad8\u65bc\u7dad\u751f\u7d20C\u53ca\u7dad\u751f\u7d20E\u7b49\u65e5\u5e38\u6297\u6c27\u5316\u5291\uff0c\u8591\u9ec3\u7d20\u7684\u6297\u6c27\u5316\u529b\u50f9\uff0c\u662f\u7dad\u751f\u7d20E\u76841.60\u500d\uff0c\u662f\u9ec3\u916e\u985e\u6297\u6c27\u5316\u5291\u76842.33\u500d\uff0c\u66f4\u662f\u7dad\u751f\u7d20C\u76842.75\u500d\uff01 \u6b63\u56e0\u70ba\u8591\u9ec3\u7d20\u5177\u6709\u5f37\u6548\u7684\u6297\u6c27\u5316\u529f\u80fd\uff0c\u80fd\u5920\u62b5\u6297\u7d2b\u5916\u7dda\u7522\u751f\u7684\u81ea\u7531\u57fa\uff0c\u9032\u800c\u53ef\u4ee5\u9054\u6210\u76ae\u819a\u6297\u8001\u7684\u4f5c\u7528\uff0c\u56e0\u6b64\u53ef\u7a31\u4e4b\u70ba” \u53e3\u670d\u7684\u76ae\u819a\u4fdd\u990a\u54c1”\u3002<\/p>\n\n\n\n
\u4e8c.\u6355\u6349\u81ea\u7531\u57fa\uff0c\u6e1b\u5c11\u75be\u75c5\u5a01\u8105<\/p>\n\n\n\n
\u5f9e\u751f\u7269\u7684\u89c0\u9ede\u4f86\u770b\uff0c\u751f\u7269\u90fd\u662f\u7531\u5206\u5b50\u6240\u69cb\u6210\uff0c\u4e00\u500b\u7a69\u5b9a\u7684\u5206\u5b50\u5305\u542b\u6210\u5c0d\u7684\u96fb\u5b50\uff0c\u81ea\u7531\u57fa\u4fc2\u6307\u4e00\u500b\u6216\u4e00\u500b\u4ee5\u4e0a\u7684\u4e0d\u6210\u5c0d\u96fb\u5b50\uff0c\u7531\u65bc\u5947\u6578\u7684\u96fb\u5b50\u5f88\u4e0d\u5b89\u5b9a\uff0c\u5177\u6709\u9ad8\u5ea6\u7684\u6d3b\u8e8d\u6027\uff0c\u6703\u53bb\u653b\u64ca\u6b63\u5e38\u7d30\u80de\uff0c\u5f15\u8d77\u9ad4\u5167\u7d44\u7e54\u8b8a\u5316\uff0c\u5c0e\u81f4\u75be\u75c5\u767c\u751f\u3002\u81ea\u7531\u57fa\u53ef\u80fd\u53c3\u8207\u7684\u75be\u75c5\u5305\u62ec\uff1a\u52d5\u8108\u786c\u5316\u75c7\u3001\u7cd6\u5c3f\u75c5\u3001\u95dc\u7bc0\u708e\u3001\u767d\u5167\u969c\u3001\u8001\u5316\u3001\u51a0\u72c0\u52d5\u8108\u75be\u75c5\u3001\u81ea\u9ad4\u514d\u75ab\u75be\u75c5\u3001\u764c\u75c7\u7b49\u7b49\u3002<\/p>\n\n\n\n
\u8591\u9ec3\u7d20\u8eab\u517c\u96d9\u91cd\u5c0d\u6297\u81ea\u7531\u57fa\u4f5c\u7528\uff1a\u4e00\u65b9\u9762\u76f4\u63a5\u6349\u53d6\u81ea\u7531\u57fa (ROS\uff0c\u5c24\u5176\u662f\uff0eOH\u81ea\u7531\u57fa)\uff1b\u53e6\u4e00\u65b9\u9762\u5247\u76f4\u63a5\u6291\u5236\u81ea\u7531\u57fa\u751f\u6210\u9175\u7d20\uff0c\u5982arachidonate-cascade enzymes(cyclo-oxygenase\u53calipoxygenase)\u548cXO(xanthine oxidase)\u7684\u6d3b\u6027\uff0c\u4ee5\u9593\u63a5\u5730\u6e1b\u5c11\u81ea\u7531\u57fa\u7684\u7522\u751f\u3002\u7531\u65bc\u8591\u9ec3\u7d20\u900f\u904e\u4e0d\u53ea\u4e00\u7a2e\u9014\u5f91\u5c0d\u6297\u81ea\u7531\u57fa\uff0c\u6240\u4ee5\u6bd4\u5176\u4ed6\u6297\u6c27\u5316\u5291\u66f4\u80fd\u6709\u6548\u5730\u6355\u6349\u81ea\u7531\u57fa\uff0c\u6e1b\u5c11\u75be\u75c5\u5c0d\u4eba\u9ad4\u5065\u5eb7\u7684\u5a01\u8105\u3002<\/p>\n\n\n\n
\u4e09.\u6291\u5236DNA\u4e0d\u6b63\u5e38\u589e\u751f\uff0c\u9054\u5230\u9810\u9632\u764c\u75c7<\/p>\n\n\n\n
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1.\u8591\u9ec3\u7d20\u53ef\u6291\u5236 TPA\u4e4b\u6d3b\u6027\uff0cTPA\uff0812-0-teradecanoylphorbol-13-acetate\uff09\u5177\u6709\u5f88\u5f37\u7684\u4fc3\u764c\uff08tumor promoter\uff09\u80fd\u529b\uff0c\u800c\u8591\u9ec3\u7d20\u5247\u88ab\u8b49\u5be6\u5177\u6709\u76f8\u7576\u6709\u6548\u7684\u6291\u5236TPA\u4fc3\u764c\u4f5c\u7528\u7684\u80fd\u529b\u3002<\/p>\n\n\n\n
2.\u8591\u9ec3\u7d20\u53ef\u6291\u5236NOS\u4e4b\u6d3b\u6027\uff0cNOS\uff08Nitric oxide synthase\uff09\u6703\u4f7f\u9ad4\u5167\u7d30\u80de\u7522\u751f\u4e0d\u826f\u4ee3\u8b1d\u7522\u7269\uff0c\u9019\u4e9b\u7522\u7269\u6703\u653b\u64caDNA\u5206\u5b50\u5f15\u8d77\u4fc3\u764c\u4f5c\u7528\u3002\u7531\u65bc\u8591\u9ec3\u7d20\u53ef\u6291\u5236NOS\u7684\u6d3b\u6027\uff0c\u6240\u4ee5\u6709\u9810\u9632\u764c\u75c7\u7684\u529f\u6548\u3002<\/p>\n\n\n\n
3.\u8591\u9ec3\u7d20\u53ef\u6291\u5236\u81f4\u764c\u57fa\u56e0c-Jun\u4e4b\u8868\u73fe\uff0cc-Jun\u5728\u50b3\u905e\u4fc3\u764c\u8a0a\u606f\u81f3\u7d30\u80de\u5f15\u8d77\u8f49\u9304\u4f5c\u7528\u626e\u6f14\u95dc\u9375\u6027\u89d2\u8272\uff0c\u8591\u9ec3\u7d20\u53ef\u6291\u5236\u6b64\u57fa\u56e0\u7684\u8868\u73fe\uff0c\u63d0\u4f9b\u8591\u9ec3\u7d20\u9632\u764c\u7684\u5206\u5b50\u57fa\u790e\u7406\u8ad6\u3002<\/p>\n\n\n\n
4.\u8591\u9ec3\u7d20\u53ef\u5f15\u8d77\u764c\u7d30\u80de\u7684\u51cb\u6b7b\uff08apoptosis\uff09\uff0c\u662f\u7d44\u7e54\u4e2d\u63a7\u5236\u7d30\u80de\u6578\u76ee\u7684\u65b9\u6cd5\uff0c\u8591\u9ec3\u7d20\u53ef\u5f15\u8d77\u764c\u7d30\u80de\u7684\u51cb\u6b7b\uff0c\u4f46\u5c0d\u6b63\u5e38\u7d30\u80de\u5247\u8f03\u7121\u6b64\u4f5c\u7528\uff0c\u6240\u4ee5\u8591\u9ec3\u7d20\u5177\u6709\u5316\u5b78\u9632\u764c\u5291\uff08chemopreventive agent\uff09\u4e4b\u529f\u6548\u3002<\/p>\n\n\n\n
\u56db.\u4e2d\u548c\u74b0\u5883\u6bd2\u7d20\u5165\u4fb5\u9ad4\u5167<\/p>\n\n\n\n
\u7d2b\u5916\u7dda\u8f3b\u5c04\u6703\u9020\u6210\u4eba\u9ad4\u57fa\u56e0\u7684\u7a81\u8b8a\uff0c\u4e3b\u8981\u662f\u7531\u65bc\u7d2b\u5916\u7dda\u6703\u4f7f\u4eba\u9ad4\u7522 SOS\uff08umu C\uff09\u800c\u9020\u6210\u907a\u50b3\u8a0a\u606f\u932f\u8aa4\uff0c\u8591\u9ec3\u7d20\u80fd\u5920\u6709\u6548\u6291\u5236umu C \u7684\u8a98\u5c0e\u4f5c\u7528\u3002<\/p>\n\n\n\n
\u4e94.\u5177\u6709\u8178\u80c3\u4fdd\u5065\u529f\u6548\uff0c\u6e1b\u7de9\u6162\u6027\u80c3\u6f70\u760d\u76f8\u95dc\u75c7\u72c0<\/p>\n\n\n\n
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\u516d.\u589e\u5f37\u9ad4\u5167\u9632\u79a6\u529f\u80fd<\/p>\n\n\n\n
South\u7b49\u4eba\u65bc1997\u5e74\u9935\u98df\u5154\u5b50\u8591\u9ec3\u7d20\u9032\u884c\u5be6\u9a57\uff0c\u767c\u73fe\u5154\u5b50\u57285\u9031\u5f8c\u6297\u9ad4\u6578\u91cf\u660e\u986f\u589e\u52a0\uff0c\u986f\u793a\u8591\u9ec3\u7d20\u5177\u6709\u589e\u5f37\u9ad4\u5167\u9632\u79a6\u4e4b\u529f\u80fd\u3002<\/p>\n\n\n\n
\u4e03.\u5177\u6297\u767c\u708e\u529f\u80fd<\/p>\n\n\n\n
\u6839\u64daSatoskar\u7b49\u4eba\u8591\u9ec3\u7d20\u8207NSAID\uff08\u975e\u985e\u56fa\u9187\u6297\u767c\u708e\u85e5\uff09\u9032\u884c\u96d9\u76f2\u5be6\u9a57\u7d50\u679c\u8b49\u5be6\uff0c\u5169\u8005\u5c0d\u65bc\u6297\u767c\u708e\u6548\u679c\u4e26\u7121\u986f\u8457\u5dee\u7570\uff0c\u7136\u8591\u9ec3\u7d20\u4e26\u7121\u4e00\u822c\u6297\u767c\u708e\u85e5\u7684\u526f\u4f5c\u7528\u3002<\/p>\n\n\n\n
\u516b.\u964d\u4f4e\u81bd\u56fa\u9187<\/p>\n\n\n\n
\u6839\u64daSoni\u53caKuttan\u65bc1992\u5e74\u767c\u8868\u5831\u544a\u6240\u8ff0\uff0c\u8591\u9ec3\u7d20\u53ef\u964d\u4f4e\u7e3d\u81bd\u56fa\u918711.6%\uff0c\u4e26\u53ef\u63d0\u9ad8HDL\uff08\u597d\u7684\u81bd\u56fa\u9187\uff0929%\uff0c\u6709\u52a9\u65bc\u9810\u9632\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u767c\u751f\u3002<\/p>\n\n\n\n
\u529f\u6548\uff1a<\/p>\n\n\n\n
\u9810\u9632\u8840\u7403\u5f7c\u6b64\u9644\u8457\u5f62\u6210\u5371\u96aa\u7684\u8840\u584a\u3001\u5c0d\u809d\u6a5f\u80fd\u6709\u52a9\u76ca\u3001\u5e6b\u52a9\u9810\u9632\u81bd\u75be\u3001\u6e1b\u8f15\u95dc\u7bc0\u708e\u7684\u75c7\u72c0\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"
\u4e00.\u5177\u6297\u6c27\u5316\u529f\u80fd\uff0c\u4ee5\u5ef6\u7de9\u8001\u5316 \u64da\u7814\u7a76\u6307\u51fa\uff0c\u65e5\u5149\u4e2d\u7684\u7d2b\u5916\u7dda\u662f\u76ae\u819a\u8001\u5316\u7684\u4e3b\u8981\u6bba\u624b\uff0c\u7d2b\u5916\u7dda\u7522\u751f\u7684\u81ea\u7531\u57fa\u80fd\u9020\u6210\u808c\u819a\u4e2d\u7684\u81a0\u539f\u86cb\u767d\u5f48\u529b\u86cb\u767d\u7684\u53d7\u640d\uff0c\u9032\u800c\u4f7f\u76ae\u819a\u7684\u7dca\u5bc6\u5ea6\u8b8a\u5dee\uff0c\u4fdd\u6c34\u6027\u4e5f\u4e0b\u964d\uff0c\u56e0\u6b64\u770b\u8d77\u4f86\u7121\u5149\u6fa4\u800c\u5bb9\u6613\u7522\u751f\u76ba\u7d0b\u3002\u6839\u64da\u7f8e\u570b\u77e5\u540d\u671f\u520a\uff08J. Am. Chem. 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