{"id":61,"date":"2020-11-04T02:57:58","date_gmt":"2020-11-04T02:57:58","guid":{"rendered":"http:\/\/203.174.43.78\/1tohealth\/blog\/?p=61"},"modified":"2020-11-05T02:24:56","modified_gmt":"2020-11-05T02:24:56","slug":"%e8%96%91%e9%bb%83%e7%b4%a0%e6%8a%97%e7%99%bc%e7%82%8e","status":"publish","type":"post","link":"http:\/\/203.174.43.78\/1tohealth\/blog\/2020\/11\/04\/%e8%96%91%e9%bb%83%e7%b4%a0%e6%8a%97%e7%99%bc%e7%82%8e\/","title":{"rendered":"\u8591\u9ec3\u53ca\u8591\u9ec3\u7c89 17 \u7a2e\u53ef\u80fd\u529f\u6548\u53ca\u526f\u4f5c\u7528\u5168\u653b\u7565\uff01"},"content":{"rendered":"\n<p>\u8591\u9ec3\u7d20\uff08Curcumin\uff09\u53ef\u4ee5\u8aaa\u662f\u8fd1\u5e74\u4f86\u6700\u591a\u7814\u7a76\u8005\u8da8\u4e4b\u82e5\u9da9\u505a\u7814\u7a76\u7684\u7269\u8cea\u4e4b\u4e00\uff0c\u5b83\u662f\u8591\u9ec3\uff08Curmuma&nbsp;<em>longa<\/em>&nbsp;L.\uff09\u4e2d\u542b\u6709\u7684\u6210\u5206\u3002\u5728\u9019\u908a\u6211\u5011\u5148\u8aaa\u4e00\u90e8\u5206\u7d50\u8ad6\uff1a\u82e5\u4eba\u9ad4\u5438\u6536\u4e86\u8db3\u5920\u5291\u91cf\u7684\u8591\u9ec3\u7d20\uff0c\u78ba\u5be6\u5728\u67d0\u4e9b\u554f\u984c\u5177\u6709\u4e00\u4e9b\u529f\u6548\uff0c\u4f46\u7db2\u8def\u4e0a\u4f60\u5982\u679c\u770b\u5230<strong>\u300c\u8591\u9ec3\u529f\u80fd\u6253\u6557\u897f\u85e5\u300d<\/strong>\u9019\u985e\u7684\u8ad6\u9ede\uff0c\u4f60\u5c31\u5148<strong>\u7b11\u7b11\u5c31\u7b97\u4e86<\/strong>\uff0c\u5be6\u969b\u4e0a\u76ee\u524d\u7684\u7814\u7a76\u8ddd\u96e2\u300c\u6253\u6557\u897f\u85e5\u300d\u9084\u6709\u5f88\u5927\u7684\u8ddd\u96e2\u554a\uff5e<\/p>\n\n\n\n<ul><li>1. \u6297\u767c\u708e<br>\u5404\u7a2e\u5206\u5b50\u7814\u7a76\u5df2\u7d93\u8b49\u5be6\u8591\u9ec3\u7d20\u53ef\u4ee5\u6291\u5236\u4fc3\u767c\u708e\u56e0\u5b50\uff0c\u5728\u4ee5\u8102\u591a\u91a3\u523a\u6fc0\u4eba\u985e\u8840\u6db2\u7684\u5be6\u9a57\u6a21\u5f0f\u4e2d\uff0c\u767c\u73fe\u8591\u9ec3\u7d20\u53ef\u4ee5\u900f\u904e\u6291\u5236&nbsp;PGE2&nbsp;\u5408\u6210\u9176&nbsp;1&nbsp;\u7684\u6d3b\u6027\u4f86\u6e1b\u5c11\u4fc3\u767c\u708e\u7d30\u80de\u6fc0\u7d20&nbsp;PGE2&nbsp;\u7684\u751f\u5408\u6210\uff08Ref 33\uff09\uff1b\u5728\u5c0f\u9f20\u5de8\u566c\u7d30\u80de\u4ee5\u53ca\u4eba\u985e\u5927\u8178\u764c\u7d30\u80de\u6a21\u5f0f\u4e2d\uff0c\u540c\u6a23\u8b49\u5be6\u4e86\u8591\u9ec3\u7d20\u53ef\u4ee5\u6291\u5236\u7531\u8102\u591a\u91a3\u6240\u8a98\u767c\u7684&nbsp;COX-2&nbsp;\u8868\u73fe\uff0c\u9032\u800c\u53ef\u80fd\u6e1b\u5c11&nbsp;PGE2&nbsp;\u7684\u751f\u6210\uff08Ref 35\uff09\uff1b\u5728\u5b50\u5bae\u9838\u764c\u7d30\u80de\u682a\u7684\u5be6\u9a57\u4e2d\u767c\u73fe\u8591\u9ec3\u7d20\u6703\u4fc3\u9032\u764c\u7d30\u80de\u7684\u51cb\u4ea1\uff0c\u6b64\u5916\u4e5f\u6703\u6291\u5236&nbsp;AP-1&nbsp;\u4ee5\u53ca&nbsp;NF-kB&nbsp;\u7684\u8868\u73fe\uff08Ref 34\uff09\uff1b\u53e6\u5916\u4e00\u7bc7\u5c0f\u9f20\u7d30\u80de\u682a\u7684\u5be6\u9a57\u5247\u767c\u73fe\u8591\u9ec3\u7d20\u53ef\u4ee5\u6291\u5236\u4fc3\u767c\u708e\u7d30\u80de\u6fc0\u7d20IL-18\uff08Ref 36\uff09\u3002<br><strong>\u8591\u9ec3\u7d20\u88ab\u767c\u73fe\u53ef\u900f\u904e\u6291\u5236\u7279\u5b9a\u9175\u7d20\u7684\u6d3b\u6027\uff0c\u4f86\u964d\u4f4e\u767c\u708e\u7d30\u80de\u7522\u751f\u7684\u767c\u708e\u53cd\u61c9\u3002\u4f46\u9019\u4e9b\u7814\u7a76\u7d50\u679c\u548c\u5be6\u969b\u4eba\u9ad4\u5be6\u9a57\u9084\u6709\u8ddd\u96e2\u3002<\/strong>&nbsp;\u67e5\u770b\u5176\u4ed6\u53ef\u80fd\u529f\u6548&nbsp;<\/li><\/ul>\n\n\n\n<ul><li>2. \u6297\u6c27\u5316<br>\u6c27\u5316\u4e00\u822c\u4f86\u8aaa\u88ab\u8a8d\u70ba\u548c\u4eba\u9ad4\u8001\u5316\u6709\u95dc\uff0c\u56e0\u6b64\u6297\u6c27\u5316\u80fd\u529b\u901a\u5e38\u88ab\u8a8d\u70ba\u662f\u4e00\u7a2e\u6297\u8001\u5316\u80fd\u529b\u3002\u5728\u7d30\u80de\u5be6\u9a57\u4e2d\u767c\u73fe\u8591\u9ec3\u7d20\u5177\u6709\u900f\u904e\u4fc3\u9032\u8840\u7d05\u7d20\u4e2d\u7684\u7279\u5b9a\u9175\u7d20\u8868\u73fe\uff0c\u7522\u751f\u4fdd\u8b77\u7d30\u80de\u62b5\u6297\u6c27\u5316\u58d3\u529b\u7684\u529f\u80fd\uff08Ref &nbsp;37\uff09\uff1b\u5728\u53e6\u4e00\u500b\u5c0f\u9f20\u7d30\u80de\u7684\u5be6\u9a57\u4e2d\uff0c\u4e5f\u767c\u73fe\u8591\u9ec3\u7d20\u6709\u6297\u6c27\u5316\u7684\u80fd\u529b\uff08Ref 38\uff09\u3002\u5728\u4e00\u7bc7\u7cd6\u5c3f\u75c5\u5c0f\u9f20\u7684\u52d5\u7269\u5be6\u9a57\u4e2d\u5247\u767c\u73fe\uff0c\u651d\u53d6\u8591\u9ec3\u7d20\u7684\u5c0f\u9f20\u8840\u6e05\u4e2d\u8d85\u6c27\u5316\u7269\u6b67\u5316\u9176\uff08SOD\uff09\u7684\u542b\u91cf\u6bd4\u8f03\u591a\uff0cSOD&nbsp;\u662f\u4e00\u7a2e\u6297\u6c27\u5316\u7269\u3002\u56e0\u6b64<strong>\u5728\u7d30\u80de\u5be6\u9a57\u53ca\u52d5\u7269\u5be6\u9a57\u4e2d\uff0c\u8591\u9ec3\u88ab\u8a8d\u70ba\u5177\u6709\u4e00\u5b9a\u7684\u6297\u6c27\u5316\u80fd\u529b\u3002<br><\/strong>&nbsp;\u67e5\u770b\u5176\u4ed6\u53ef\u80fd\u529f\u6548&nbsp;<\/li><\/ul>\n\n\n\n<ul><li>3. \u9810\u9632\u5fc3\u8840\u7ba1\u75be\u75c5\u56e0\u70ba\u767c\u708e\u662f\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u5371\u96aa\u56e0\u5b50\u4e4b\u4e00\uff0c\u8591\u9ec3\u7d20\u7684\u6297\u767c\u708e\u80fd\u529b\u5c31\u5728\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u6cbb\u7642\u4e0a\u626e\u6f14\u4e86\u91cd\u8981\u89d2\u8272\u3002\u67d0\u7bc7\u5c0f\u9f20\u5be6\u9a57\u767c\u73fe\u7d66\u4e88\u6709\u9ad8\u8840\u58d3\u6027\u5fc3\u81df\u75be\u75c5\u7684\u5c0f\u9f20\u6bcf\u516c\u65a4\u9ad4\u91cd&nbsp;50mg&nbsp;\u7684\u8591\u9ec3\u7d20\u53ef\u4ee5\u9810\u9632\u5fc3\u81df\u8870\u7aed\u3002\uff08Ref 23\uff09<strong>\u9019\u662f\u4e00\u7bc7\u52d5\u7269\u5be6\u9a57\uff0c\u5be6\u969b\u5728\u4eba\u9ad4\u5be6\u9a57\u662f\u5426\u80fd\u767c\u63ee\u4f5c\u7528\u7684\u8b8a\u6578\u4ecd\u591a\u3002<br><\/strong>&nbsp;\u67e5\u770b\u5176\u4ed6\u53ef\u80fd\u529f\u6548&nbsp;<\/li><\/ul>\n\n\n\n<ul><li>4. \u964d\u4f4e\u8840\u4e2d\u81bd\u56fa\u9187\u00fc &nbsp;&nbsp;\u4e00\u7bc7\u7814\u7a76\u4ee5&nbsp;33&nbsp;\u4f4d\u6709\u51a0\u72c0\u52d5\u8108\u75be\u75c5\u7684\u75c5\u4eba\u70ba\u53d7\u8a66\u8005\uff0c\u5c07\u5176\u5206\u70ba\u63a7\u5236\u7d44\u4ee5\u53ca\u8591\u9ec3\u7d20\u7d44\u9032\u884c\u70ba\u671f&nbsp;8&nbsp;\u9031\u7684\u5be6\u9a57\uff0c\u63a7\u5236\u7d44\u6bcf\u5929\u5403\u56db\u6b21\u5b89\u6170\u5291\uff1b\u8591\u9ec3\u7d20\u7d44\u5247\u6bcf\u5929\u5403\u56db\u6b21\u542b&nbsp;500mg&nbsp;\u8591\u9ec3\u7d20\u7684\u81a0\u56ca\uff0c\u672c\u7bc7\u4f7f\u7528\u7684\u8591\u9ec3\u7d20\u70baCurcumin C3 complex&nbsp;\u81a0\u56ca\u3002\u7d50\u679c\u767c\u73fe\u8591\u9ec3\u7d20\u7d44\u7684\u4e09\u9178\u7518\u6cb9\u916f\u3001\u4f4e\u5bc6\u5ea6\u81bd\u56fa\u9187\u53ca\u6975\u4f4e\u5bc6\u5ea6\u81bd\u56fa\u9187\u4ecb\u5165\u5f8c\u90fd\u6bd4\u4ecb\u5165\u524d\u986f\u8457\u4e0b\u964d\u3002\uff08Ref 24\uff09\u00fc &nbsp;&nbsp;\u4e00\u7bc7\u96a8\u6a5f\u96d9\u76f2\u5be6\u9a57\u4ee5&nbsp;70&nbsp;\u4f4d\u6025\u6027\u51a0\u72c0\u52d5\u8108\u7d9c\u5408\u75c7\u60a3\u8005\u70ba\u53d7\u8a66\u8005\uff0c\u5206\u6210\u56db\u7d44\uff0c\u7b2c\u4e00\u7d44\u651d\u53d6\u5b89\u6170\u5291\u3001\u7b2c\u4e8c\u3001\u4e09\u3001\u56db\u7d44\u6bcf\u5929\u5206\u5225\u651d\u53d6&nbsp;45mg\u300190mg\u3001180mg&nbsp;\u8591\u9ec3\u7d20\uff0c\u9032\u884c\u70ba\u671f&nbsp;2&nbsp;\u500b\u6708\u7684\u4ecb\u5165\u3002\u7d50\u679c\u767c\u73fe\u4ee5\u8591\u9ec3\u7d20\u4ecb\u5165\u4e4b\u5f8c\uff0c\u4e0d\u7ba1\u662f\u5728\u81bd\u56fa\u9187\u3001\u4f4e\u5bc6\u5ea6\u81bd\u56fa\u9187\u3001\u9ad8\u5bc6\u5ea6\u81bd\u56fa\u9187\u4ee5\u53ca\u4e09\u9178\u7518\u6cb9\u916f\uff0c\u8207\u4ecb\u5165\u524d\u90fd\u6c92\u6709\u986f\u8457\u5dee\u7570\u3002\uff08Ref 25\uff09\u00fc &nbsp;&nbsp;\u4e00\u7bc7\u8f03\u4e45\u4ee5\u524d\u7684\u7814\u7a76\uff0c\u8b93&nbsp;10&nbsp;\u4f4d\u5065\u5eb7\u53d7\u8a66\u8005\u651d\u53d6&nbsp;500mg&nbsp;\u7684\u8591\u9ec3\u7d20\u81a0\u56ca\uff0c\u4ecb\u5165\u6642\u9593\u70ba&nbsp;7&nbsp;\u5929\u3002\u7d50\u679c\u767c\u73fe\u8840\u6e05\u8102\u8cea\u904e\u6c27\u5316\u7269\u986f\u8457\u4e0b\u964d&nbsp;33%\u3001\u7e3d\u81bd\u56fa\u9187\u986f\u8457\u4e0b\u964d&nbsp;11.63%\u3001\u9ad8\u5bc6\u5ea6\u81bd\u56fa\u9187\u5247\u986f\u8457\u63d0\u5347&nbsp;29%\u3002\uff08Ref 26\uff09<br>\u7d9c\u5408\u4ee5\u4e0a\u4e09\u7bc7\u7814\u7a76\u7d50\u679c\u800c\u8ad6\uff0c<strong>\u8591\u9ec3\u7d20\u5c0d\u65bc\u8840\u8102\u80aa\u7684\u4e0b\u964d\u6548\u679c\u6216\u8a31\u8207\u5291\u91cf\u6709\u95dc\uff0c\u8f03\u4f4e\u5291\u91cf\u7684\u8591\u9ec3\u7d20\u7121\u6cd5\u6709\u6548\u6539\u5584\u8840\u4e2d\u7684\u81bd\u56fa\u9187\u6216\u4e09\u9178\u7518\u6cb9\u916f\uff0c\u56e0\u6b64\u60f3\u55ae\u7d14\u9760\u98df\u7269\u6216\u8591\u9ec3\u7c89\u4f86\u6539\u5584\u662f\u4e0d\u592a\u53ef\u80fd\u7684\u3002<\/strong>&nbsp;\u67e5\u770b\u5176\u4ed6\u53ef\u80fd\u529f\u6548&nbsp;<\/li><\/ul>\n\n\n\n<ul><li>5. \u9810\u9632\u7cd6\u5c3f\u75c5\u7814\u7a76\u767c\u73fe\uff0c\u8591\u9ec3\u7d20\u53ef\u4ee5\u6e1b\u5c11\u809d\u81df\u7684\u8461\u8404\u7cd6\u751f\u6210\uff0c\u6291\u5236\u9ad8\u8840\u7cd6\u5f15\u8d77\u7684\u767c\u708e\u53cd\u61c9\uff0c\u589e\u52a0\u7279\u5b9a\u57fa\u56e0\u8868\u73fe\u9032\u800c\u589e\u52a0\u7d30\u80de\u6c72\u53d6\u8461\u8404\u7cd6\uff0c\u56e0\u6b64\u53ef\u4ee5\u6e1b\u5c11\u80f0\u5cf6\u7d20\u62ee\u6297\u4e26\u964d\u4f4e\u8840\u7cd6\u3002\u65e9\u5728&nbsp;1972&nbsp;\u5e74\uff0c\u5c31\u6709\u7b2c\u4e00\u7bc7\u4eba\u9ad4\u5be6\u9a57\u767c\u73fe\u8591\u9ec3\u7d20\u5177\u6709\u964d\u8840\u7cd6\u7684\u6f5b\u529b\u3002\u9664\u4e86\u7cd6\u5c3f\u75c5\u672c\u8eab\uff0c\u7cd6\u5c3f\u75c5\u7684\u4f75\u767c\u75c7\uff08\u5305\u62ec\u814e\u75c5\u8b8a\u4ee5\u53ca\u8840\u7ba1\u75c5\u8b8a\uff09\u4e5f\u662f\u76ee\u524d\u5168\u7403\u5404\u570b\u9762\u81e8\u7684\u5065\u5eb7\u554f\u984c\uff0c\u5360\u4e86\u5168\u4e16\u754c\u91ab\u7642\u6d88\u8017\u7684\u5f88\u5927\u4e00\u90e8\u4efd\uff0c\u800c\u56e0\u70ba\u7cd6\u5c3f\u75c5\u800c\u6b7b\u4ea1\u7684\u6848\u4f8b\u4e3b\u8981\u4e5f\u90fd\u662f\u7531\u4f75\u767c\u75c7\u5c0e\u81f4\u3002<br><br>\u00fc &nbsp;&nbsp;\u4e00\u7bc7\u7814\u7a76\u4ee5&nbsp;14&nbsp;\u4f4d\u5065\u5eb7\u4eba\u70ba\u53d7\u8a66\u8005\u9032\u884c\u53e3\u670d\u8461\u8404\u7cd6\u8010\u53d7\u5ea6\u8a66\u9a57\uff08OGTT\u300175g\/250mL\uff09\uff0c\u5728\u559d\u7cd6\u6c34\u524d\u5148\u651d\u53d6\u5b89\u6170\u5291\u6216\u8591\u9ec3\u7d20\uff0c\u5b89\u6170\u5291\u70ba&nbsp;560mg&nbsp;\u4e73\u7cd6\uff0c\u5be6\u9a57\u7d44\u5247\u651d\u53d6&nbsp;170mg&nbsp;\u4e73\u7cd6\u53ca&nbsp;400mg&nbsp;\u8591\u9ec3\u7d20\uff0c\u7d50\u679c\u767c\u73fe\u559d\u7cd6\u6c34\u4e4b\u5f8c\u7684\u8840\u7cd6\u4ee5\u53ca\u5347\u7cd6\u6307\u6578\u5728\u5404\u6642\u9593\u9ede\u5747\u6c92\u6709\u986f\u8457\u5dee\u7570\uff0c\u800c\u651d\u53d6&nbsp;6g&nbsp;\u8591\u9ec3\u7d20\u7684\u53d7\u8a66\u8005\uff0c\u5728\u559d\u7cd6\u6c34\u5f8c&nbsp;30&nbsp;\u5206\u9418\u3001&nbsp;60&nbsp;\u5206\u9418\u8840\u6e05\u4e2d\u7684\u80f0\u5cf6\u7d20\uff0c\u4ee5\u53ca&nbsp;90&nbsp;\u5206\u9418\u5f8c\u7684\u80f0\u5cf6\u7d20\u6307\u6578\uff08insulinemic index\uff09\u5247\u662f\u6709\u986f\u8457\u63d0\u5347\uff0c\u89e3\u91cb\u4e86\u8591\u9ec3\u7d20\u5c0d\u65bc\u5065\u5eb7\u4eba\u53ef\u80fd\u6709\u4fc3\u9032\u80f0\u5cf6\u7d20\u5206\u6ccc\u7684\u6548\u679c\u3002\uff08Ref 27\uff09\u00fc &nbsp;&nbsp;\u4e00\u7bc7\u5927\u578b\u7684\u96a8\u6a5f\u96d9\u76f2\u5be6\u9a57\u4ee5&nbsp;240&nbsp;\u4f4d\u7cd6\u5c3f\u75c5\u524d\u671f\u60a3\u8005\u70ba\u53d7\u8a66\u8005\uff0c\u5206\u6210\u63a7\u5236\u7d44\u53ca\u5be6\u9a57\u7d44\u9032\u884c\u70ba\u671f&nbsp;9&nbsp;\u500b\u6708\u7684\u4ecb\u5165\uff0c\u6bcf\u5929\u5206\u5169\u6b21\u651d\u53d6\u516d\u9846\u5b89\u6170\u5291\u6216\u8591\u9ec3\u7d20\u81a0\u56ca\u3002\u672c\u7bc7\u7814\u7a76\u7684\u4f7f\u7528\u7684\u8591\u9ec3\u81a0\u56ca\u662f\u4ee5\u8591\u9ec3\u6839\u90e8\u78e8\u7c89\uff0c\u4e59\u9187\u8403\u53d6\uff0c\u6700\u7d42\u6bcf\u9846\u81a0\u56ca\u5927\u7d04\u542b\u6709&nbsp;250mg&nbsp;\u7684\u985e\u8591\u9ec3\u7d20\uff0c\u56e0\u6b64\u5be6\u9a57\u7d44\u7684\u8591\u9ec3\u7d20\u5291\u91cf\u7d04\u70ba&nbsp;1500mg\u3002\u7d50\u679c\u767c\u73fe\u4ecb\u5165\u5f8c\u7684&nbsp;3\u30016\u30019&nbsp;\u500b\u6708\u5be6\u9a57\u7d44\u7684\u7a7a\u8179\u8840\u7cd6\u3001\u7cd6\u5316\u8840\u8272\u7d20\u3001\u53e3\u670d\u8461\u8404\u7cd6\u8010\u53d7\u6027\u8a66\u9a57\u7684\u5e73\u5747\u503c\u90fd\u986f\u8457\u4f4e\u65bc\u63a7\u5236\u7d44\uff1b\u5be6\u9a57\u7d44\u8840\u6e05\u4e2d\u7684&nbsp;HOMA-b&nbsp;\u5230\u4e86\u7b2c&nbsp;9&nbsp;\u500b\u6708\u4e4b\u5f8c\u986f\u8457\u5730\u6bd4\u63a7\u5236\u7d44\u9ad8\u3001C-peptide&nbsp;\u5247\u986f\u8457\u6bd4\u63a7\u5236\u7d44\u4f4e\uff1b\u81e8\u5e8a\u4e0a\u53ef\u4ee3\u8868\u80f0\u5cf6\u7d20\u6297\u6027\u7684&nbsp;HOMA-IR&nbsp;\u5728\u4ecb\u5165\u5f8c\u7684&nbsp;3\u30016\u30019&nbsp;\u500b\u6708\u5be6\u9a57\u7d20\u7d44\u90fd\u986f\u8457\u5730\u6bd4\u63a7\u5236\u7d44\u4f4e\uff1b\u8102\u806f\u7d20\uff08adiponectin\uff09\uff0c\u4e00\u7a2e\u6297\u767c\u708e\u7684\u7d30\u80de\u6fc0\u7d20\uff0c\u63a7\u5236\u7d44\u5728\u4ecb\u5165\u524d\u5f8c\u6c92\u6709\u592a\u5927\u8b8a\u5316\uff0c\u5be6\u9a57\u7d44\u5247\u662f\u5728\u4ecb\u5165\u5f8c\u7b2c&nbsp;3\u30016&nbsp;\u500b\u6708\u90fd\u6709\u4e0a\u5347\uff0c\u76f4\u5230\u7b2c&nbsp;9&nbsp;\u500b\u6708\u8102\u806f\u7d20\u7684\u6fc3\u5ea6\u986f\u8457\u7684\u6bd4\u63a7\u5236\u7d44\u9ad8\uff1b\u6700\u7d42\uff0c\u63a7\u5236\u7d44\u7684\u53d7\u8a66\u8005\u5728\u7b2c&nbsp;6\u30019\u300112&nbsp;\u500b\u6708\u5206\u5225\u6709&nbsp;11&nbsp;\u4f4d\u300118&nbsp;\u4f4d\u53ca&nbsp;19&nbsp;\u4f4d\u9032\u5c55\u70ba\u7cd6\u5c3f\u75c5\uff0c\u5be6\u9a57\u7d44\u5247\u6c92\u6709\u4efb\u4f55\u4e00\u4f4d\u53d7\u8a66\u8005\u9032\u5c55\u70ba\u7cd6\u5c3f\u75c5\u3002\uff08Ref 28\uff09<br>\u7d9c\u5408\u4ee5\u4e0a\u7814\u7a76\uff0c<strong>\u5728\u6975\u9ad8\u6fc3\u5ea6\u7684\u8591\u9ec3\u7d20\u651d\u53d6\u4e0b\uff0c\u53ef\u80fd\u6709\u63a7\u5236\u8840\u7cd6\u7684\u6548\u679c\u3002\u4f46\u4f4e\u6fc3\u5ea6\u662f\u5426\u4ecd\u6709\u6548\u679c\u672a\u77e5\uff0c\u53e6\u5916\u6b64\u7814\u7a76\u9032\u884c\u4e5d\u500b\u6708\uff0c\u7f3a\u4e4f\u9577\u671f\u7684\u8ffd\u8e64\uff0c\u56e0\u6b64\u9ad8\u6fc3\u5ea6\u8591\u9ec3\u7d20\u9577\u671f\u651d\u53d6\u7684\u5b89\u5168\u6027\u672a\u77e5\u3002<\/strong>&nbsp;\u67e5\u770b\u5176\u4ed6\u53ef\u80fd\u529f\u6548&nbsp;<\/li><\/ul>\n\n\n\n<ul><li>6. \u7cd6\u5c3f\u75c5\u814e\u75c5\u8b8a\u00fc &nbsp;&nbsp;\u4e00\u7bc7\u96a8\u6a5f\u96d9\u76f2\u5be6\u9a57\u4ee5&nbsp;40&nbsp;\u4f4d\u6709\u7cd6\u5c3f\u75c5\u814e\u75c5\u8b8a\u7684\u60a3\u8005\u70ba\u53d7\u8a66\u8005\uff0c\u5206\u6210\u63a7\u5236\u7d44\u53ca\u5be6\u9a57\u7d44\uff0c\u9032\u884c\u70ba\u671f&nbsp;2&nbsp;\u500b\u6708\u7684\u4ecb\u5165\uff0c\u5176\u4e2d\u5be6\u9a57\u7d44\u6bcf\u5929\u651d\u53d6&nbsp;3&nbsp;\u6b21&nbsp;500mg&nbsp;\u7684\u8591\u9ec3\u81a0\u56ca\uff0c\u6bcf\u9320\u4e2d\u7d04\u6709&nbsp;22.1mg&nbsp;\u8591\u9ec3\u7d20\uff1b\u63a7\u5236\u7d44\u5247\u651d\u53d6\u5916\u89c0\u8207\u5be6\u9a57\u7d44\u76f8\u540c\u7684\u5b89\u6170\u5291\u3002\u7d50\u679c\u767c\u73fe\u8207\u4ecb\u5165\u524d\u76f8\u6bd4\uff0c\u5be6\u9a57\u7d44\u5c3f\u6db2\u4e2d\u7684&nbsp;IL-8&nbsp;\u4ee5\u53ca\u86cb\u767d\u8cea\u3001\u8840\u6e05\u4e2d\u7684&nbsp;TGF-b&nbsp;\u4ee5\u53ca&nbsp;IL-8&nbsp;\u90fd\u6709\u986f\u8457\u4e0b\u964d\u3002\uff08Ref 29\uff09<br><strong>\u5728\u77ed\u671f\u9593\u4f7f\u7528\u9ad8\u6fc3\u5ea6\u8591\u9ec3\u7d20\uff0c\u5c0d\u65bc\u7cd6\u5c3f\u75c5\u814e\u75c5\u8b8a\u7684\u63a7\u5236\u53ef\u80fd\u6709\u5e6b\u52a9\u3002<br><\/strong>&nbsp;\u67e5\u770b\u5176\u4ed6\u53ef\u80fd\u529f\u6548&nbsp;<\/li><\/ul>\n\n\n\n<ul><li>7. \u7cd6\u5c3f\u75c5\u5fae\u8840\u7ba1\u75c5\u8b8a\u00fc &nbsp;&nbsp;\u4e00\u7bc7\u7814\u7a76\u4ee5\u6c92\u6709\u300c\u52d5\u8108\u7ca5\u72c0\u786c\u5316\u300d\u6216\u300c\u5fc3\u8840\u7ba1\u75be\u75c5\u98a8\u96aa\u56e0\u5b50\u300d\u7684\u7cd6\u5c3f\u75c5\u60a3\u8005\u70ba\u53d7\u8a66\u8005\uff0c\u5be6\u9a57\u7d44\u4e00\u5929\u651d\u53d6&nbsp;2&nbsp;\u6b21&nbsp;Meriva\uff08\u4e00\u7a2e\u8591\u9ec3\u7d20\u8207\u78f7\u8102\u91af\u81bd\u9e7c\u8907\u5408\u7684\u7522\u54c1\uff09\uff0c\u6bcf\u5929\u5291\u91cf\u70ba&nbsp;1g\uff0c\u4ecb\u5165\u6642\u9593\u70ba&nbsp;4&nbsp;\u9031\u3002\u7d50\u679c\u767c\u73fe\u4ecb\u5165\u4e4b\u5f8c\u76ae\u819a\u8868\u9762\u7684\u4f11\u606f\u8840\u6d41\u91cf\u6709\u986f\u8457\u6e1b\u5c11\u7684\u60c5\u6cc1\uff0c\u4e00\u822c\u7cd6\u5c3f\u75c5\u5fae\u8840\u7ba1\u75c5\u8b8a\u7684\u60a3\u8005\u8840\u6d41\u91cf\u90fd\u6703\u589e\u52a0\uff0c\u89e3\u91cb\u8591\u9ec3\u7d20\u5c0d\u65bc\u5fae\u8840\u7ba1\u75c5\u8b8a\u53ef\u80fd\u6709\u6539\u5584\u7684\u6548\u679c\uff1b\u53e6\u5916\u4e5f\u89c0\u5bdf\u5230\u6c34\u816b\u72c0\u6cc1\u986f\u8457\u6539\u5584\uff1b\u975c\u8108\u2014\u52d5\u8108\u53cd\u61c9\uff08venoarteriolar response\uff09\u986f\u8457\u63d0\u5347\uff1bPO2&nbsp;\u4e0a\u5347\u7684\u60c5\u5f62\uff0c\u4f5c\u8005\u63a8\u6e2c\u53ef\u80fd\u662f\u7531\u65bc\u6c27\u6c23\u64f4\u6563\u5230\u76ae\u819a\u7684\u72c0\u6cc1\u8f03\u597d\uff0c\u4e14\u6c34\u816b\u6539\u5584\u7684\u7de3\u6545\u3002\uff08Ref 30\uff09<br>\u76ee\u524d\u7684\u7814\u7a76\u986f\u793a<strong>\u8591\u9ec3\u5c0d\u7cd6\u5c3f\u75c5\u70ba\u8840\u7ba1\u75c5\u8b8a\u53ef\u80fd\u6709\u5e6b\u52a9\uff0c\u4f46\u6a5f\u5236\u4e0d\u660e\u78ba\u3002<\/strong>&nbsp;\u67e5\u770b\u5176\u4ed6\u53ef\u80fd\u529f\u6548&nbsp;<\/li><\/ul>\n\n\n\n<ul><li>8. \u80a5\u80d6\u8591\u9ec3\u7d20\u53ef\u4ee5\u6291\u5236\u7d72\u88c2\u539f\u6d3b\u5316\u86cb\u767d\u6fc0\u9176\uff08MAPK, ERK, JNK, and p38\uff09\uff0c\u800c\u9019\u4e9b\u6fc0\u9176\u8207&nbsp;3T3-L1&nbsp;\u7d30\u80de\u682a\u5206\u5316\u6210\u70ba\u8102\u80aa\u7d30\u80de\u76f8\u95dc\uff0c\u5728\u5df2\u5206\u5316\u7684\u8102\u80aa\u7d30\u80de\u4e2d\u4e5f\u6703\u6d3b\u5316&nbsp;Wnt\/\u03b2-catenin&nbsp;\u7684\u50b3\u5c0e\u9014\u5f91\u2014\u2014\u800c\u9019\u4e9b\u90fd\u8207\u80a5\u80d6\u5bc6\u4e0d\u53ef\u5206\u3002\u5728\u767d\u8272\u8102\u80aa\u7d44\u7e54\u4e2d\uff0c\u8591\u9ec3\u7d20\u53ef\u4ee5\u6e1b\u5c11\u5de8\u566c\u7d30\u80de\u6d78\u6f64\u3001\u7626\u9ad4\u7d20\uff1b\u5728\u767c\u708e\u76f8\u95dc\u7684\u80a5\u80d6\uff0c\u8591\u9ec3\u7d20\u53ef\u4ee5\u7a31\u52a0\u8102\u806f\u7d20\uff08Adeponectin\uff09\u7684\u8868\u73fe\uff0c\u6291\u5236&nbsp;NF-kB&nbsp;\u7684\u6d3b\u6027\uff0c\u56e0\u6b64\u63a8\u6e2c\u5c0d\u65bc\u80a5\u80d6\u6709\u6291\u5236\u7684\u6548\u679c\uff08Ref 1\uff09\uff0c\u4f46\u4ecd\u9700\u4eba\u9ad4\u8a66\u9a57\u4f86\u8b49\u5be6\u3002<br><strong>\u8591\u9ec3\u5c0d\u65bc\u5df2\u77e5\u8207\u80a5\u80d6\u76f8\u95dc\u7684\u9175\u7d20\u6291\u5236\u6216\u6d3b\u5316\u6709\u95dc\uff0c\u7406\u8ad6\u4e0a\u53ef\u80fd\u5c0d\u65bc\u80a5\u80d6\u6709\u6291\u5236\u6548\u679c\u3002\u4f46\u9019\u4e9b\u7814\u7a76\u8ddd\u96e2\u4eba\u9ad4\u8a66\u9a57\u9084\u6709\u5f88\u5927\u8ddd\u96e2\uff0c\u53e6\u5916\u80a5\u80d6\u662f\u591a\u91cd\u56e0\u7d20\u5f71\u97ff\uff0c\u60f3\u8981\u9760\u8591\u9ec3\u6e1b\u91cd\u7684\u8a71\u73fe\u968e\u6bb5\u9084\u662f\u5148\u5225\u5984\u60f3\u3002<\/strong>&nbsp;\u67e5\u770b\u5176\u4ed6\u53ef\u80fd\u529f\u6548&nbsp;<\/li><\/ul>\n\n\n\n<ul><li>9. \u514b\u9686\u6c0f\u75c7\uff08Crohn\u2019s disease\uff09\u56e0\u514d\u75ab\u53d7\u640d\u5c0e\u81f4\u7684\u767c\u708e\u6027\u8178\u9053\u75be\u75c5\u4e3b\u8981\u5305\u62ec\u514b\u9686\u6c0f\u75c7\uff08Crohn\u2019s disease\uff09\u4ee5\u53ca\u6f70\u760d\u6027\u5927\u8178\u708e\uff08ulcerative colitis\uff09\uff0c\u5e38\u898b\u7684\u8868\u73fe\u65b9\u5f0f\u5c31\u662f\u6d88\u5316\u7cfb\u7d71\u7684\u6162\u6027\u767c\u708e\u3002\u8591\u9ec3\u7d20\u53ef\u900f\u904e\u8a31\u591a\u50b3\u5c0e\u9014\u5f91\u4f86\u8abf\u7bc0\u767c\u708e\u53cd\u61c9\uff0c\u56e0\u6b64\u63a8\u6e2c\u5c0d\u65bc\u767c\u708e\u6027\u8178\u9053\u75be\u75c5\u5c31\u6709\u4fdd\u8b77\u7684\u6548\u679c\u3002\u00fc &nbsp;&nbsp;\u4e00\u7bc7\u524d\u77bb\u6027\u7684\u958b\u653e\u6a19\u7c64\u7814\u7a76\uff0c\u4ee5&nbsp;5&nbsp;\u4f4d\u6709\u514b\u9686\u6c0f\u75c7\u7684\u60a3\u8005\u4f5c\u70ba\u53d7\u8a66\u8005\uff0c\u9023\u7e8c&nbsp;1&nbsp;\u500b\u6708\u6bcf\u5929\u651d\u53d6\u5169\u6b21&nbsp;550mg&nbsp;\u8591\u9ec3\u7d20\uff0c\u4e4b\u5f8c&nbsp;1&nbsp;\u500b\u6708\u6bcf\u5929\u651d\u53d6\u4e09\u6b21\uff0c\u4e26\u4ee5&nbsp;Crohn\u2019s Disease Activity Index&nbsp;\u554f\u5377\u6e2c\u8a66\u505a\u70ba\u8a55\u4f30\u75c5\u60c5\u7684\u6a19\u6e96\uff0c\u7d50\u679c\u767c\u73fe\u5206\u6578\u7e3d\u5171\u4e0b\u964d\u4e86&nbsp;55&nbsp;\u5206\uff0c\u53e6\u5916\u4e5f\u89c0\u5bdf\u5230&nbsp;CRP&nbsp;\u964d\u4f4e\u7684\u73fe\u8c61\uff0c\u4f46\u56e0\u70ba\u662f\u6a23\u672c\u6578\u5c0f\u7684\u958b\u653e\u6a19\u7c64\u524d\u77bb\u6027\u7814\u7a76\uff0c<strong>\u6b64\u7d50\u679c\u5c1a\u5f85\u66f4\u5927\u578b\u7684\u96d9\u76f2\u5be6\u9a57\u4f86\u8b49\u5be6<\/strong>\uff08Ref 13\uff09\u3002\u67e5\u770b\u5176\u4ed6\u53ef\u80fd\u529f\u6548&nbsp;<\/li><\/ul>\n\n\n\n<ul><li>10. \u6f70\u760d\u6027\u5927\u8178\u708e\uff08ulcerative colitis\uff09\u00fc &nbsp;&nbsp;\u53e6\u4e00\u7bc7\u96a8\u6a5f\u5206\u914d\u7684\u96d9\u76f2\u5be6\u9a57\uff0c\u4ee5&nbsp;89&nbsp;\u4f4d\u6f70\u760d\u6027\u5927\u8178\u708e\u7684\u75c5\u60a3\u70ba\u53d7\u8a66\u8005\uff0c\u63a7\u5236\u7d44\u6bcf\u5929\u65e9\u665a\u5404\u651d\u53d6\u4e00\u6b21\u5b89\u6170\u5291\u5408\u4f75\u78fa\u80fa\u85e5\uff08Sulfasalazine\uff09\u6216&nbsp;Mesalazine\uff0c\u5be6\u9a57\u7d44\u5247\u662f\u65e9\u665a\u5404\u651d\u53d6&nbsp;1g&nbsp;\u7684\u8591\u9ec3\u7d20\u642d\u914d\u4e0a\u8ff0\u5169\u7a2e\u85e5\u7269\uff0c\u7e3d\u5171\u6301\u7e8c&nbsp;6&nbsp;\u500b\u6708\uff0c\u6700\u5f8c\u63a7\u5236\u7d44\u53ca\u5be6\u9a57\u7d44\u7684\u5fa9\u767c\u7387\u5206\u5225\u70ba&nbsp;20.51%&nbsp;\u4ee5\u53ca&nbsp;4.65%\uff08Ref 14\uff09\u3002<br>\u7d9c\u5408\u4ee5\u4e0a\u7814\u7a76\uff0c<strong>\u9ad8\u6fc3\u5ea6\u8591\u9ec3\u7d20\u651d\u53d6\u5c0d\u65bc\u6291\u5236\u767c\u708e\u6027\u8178\u9053\u75be\u75c5\u53ef\u80fd\u6709\u6548\uff0c\u4f46\u9700\u8981\u66f4\u8fd1\u4e00\u6b65\u7814\u7a76\u8b49\u5be6\u3002<\/strong>&nbsp;\u67e5\u770b\u5176\u4ed6\u53ef\u80fd\u529f\u6548&nbsp;<\/li><\/ul>\n\n\n\n<ul><li>11. \u795e\u7d93\u9000\u5316\u6027\u75be\u75c5\uff1a\u963f\u8332\u6d77\u9ed8\u75c7\u5df2\u77e5\u963f\u8332\u6d77\u9ed8\u75c7\u60a3\u8005\u8166\u90e8\u7684\u6c27\u5316\u50b7\u5bb3\u4ee5\u53ca\u767c\u708e\u53cd\u61c9\u90fd\u8f03\u70ba\u65fa\u76db\uff0c\u800c\u8591\u9ec3\u7d20\u6297\u767c\u708e\u4ee5\u53ca\u6297\u6c27\u5316\u7684\u80fd\u529b\u5df2\u7d93\u7372\u5f97\u8b49\u5be6\uff0c\u56e0\u6b64\u958b\u59cb\u51fa\u73fe\u8a31\u591a\u8591\u9ec3\u7d20\u4ee5\u53ca\u795e\u7d93\u9000\u5316\u6027\u75be\u75c5\u7684\u76f8\u95dc\u7814\u7a76\u3002\u8840\u7d05\u7d20\u6c27\u5316\u9176\uff08heme oxygenase, HO-1\uff09\u662f\u6703\u50ac\u5316\u8840\u7d05\u7d20\u5206\u89e3\u7522\u751f\u81bd\u7da0\u7d20\uff08biliverdin\uff09\u3001\u9435\u4ee5\u53ca\u4e00\u6c27\u5316\u78b3\u7684\u9175\u7d20\uff0c\u53ef\u900f\u904e\u5e6b\u52a9\u7d30\u80de\u5c0d\u6297\u6c27\u5316\u58d3\u529b\u800c\u9054\u5230\u4fdd\u8b77\u7d30\u80de\u7684\u6548\u679c\uff0c\u800c\u7814\u7a76\u767c\u73fe\u8591\u9ec3\u7d20\u53ef\u4ee5\u4fc3\u9032\u8840\u7d05\u7d20\u6c27\u5316\u9176\u7684\u6d3b\u6027\u3002\u00fc &nbsp;&nbsp;\u4e00\u7bc7\u96a8\u6a5f\u96d9\u76f2\u5be6\u9a57\u4ee5&nbsp;34&nbsp;\u4f4d\u963f\u8332\u6d77\u9ed8\u75c7\u60a3\u8005\u70ba\u53d7\u8a66\u8005\uff0c\u5206\u6210\u4e09\u7d44\uff0c\u4e00\u7d44\u651d\u53d6&nbsp;4g&nbsp;\u8207\u8591\u9ec3\u540c\u6a23\u984f\u8272\u7684\u5b89\u6170\u5291\u3001\u4e00\u7d44\u651d\u53d6&nbsp;4g&nbsp;\u8591\u9ec3\u7d20\u3001\u6700\u5f8c\u4e00\u7d44\u651d\u53d6&nbsp;1g&nbsp;\u8591\u9ec3\u7d20\u52a0&nbsp;3g&nbsp;\u5b89\u6170\u5291\uff0c\u651d\u53d6\u65b9\u5f0f\u8b93\u53d7\u8a66\u8005\u81ea\u884c\u9078\u64c7\uff0c\u5206\u70ba\u76f4\u63a5\u4ee5\u8591\u9ec3\u7c89\u5f62\u5f0f\u548c\u98df\u7269\u6df7\u5408\u8457\u5403\uff0c\u6216\u662f\u541e&nbsp;10&nbsp;\u9846\u81a0\u56ca\uff0c\u7e3d\u5171\u9032\u884c\u70ba\u671f&nbsp;6&nbsp;\u500b\u6708\u7684\u4ecb\u5165\u3002\u7d50\u679c\u767c\u73fe&nbsp;MMSE&nbsp;\u5728\u4ecb\u5165\u524d\u5f8c\u4e26\u6c92\u6709\u5dee\u7570\uff0c\u540c\u6a23\u7684\uff0c\u8840\u6e05\u4e2d\u7684&nbsp;Ab40&nbsp;\u4e5f\u6c92\u6709\u53d7\u5230\u8591\u9ec3\u7d20\u4ecb\u5165\u7684\u5f71\u97ff\uff0c\u552f\u4e00\u89c0\u5bdf\u5230\u6709\u5dee\u7570\u7684\u53ea\u6709\u8840\u6e05\u4e2d\u7684\u7dad\u751f\u7d20&nbsp;E&nbsp;\u589e\u52a0\uff0c\u4f46\u4e26\u4e0d\u80fd\u89e3\u91cb\u8591\u9ec3\u7d20\u5c0d\u65bc\u963f\u8332\u6d77\u9ed8\u75c7\u6709\u6b63\u9762\u6548\u76ca\u3002\uff08Ref 21\uff09\u00fc &nbsp;&nbsp;\u4e00\u7bc7\u96a8\u6a5f\u5be6\u9a57\u4ee5&nbsp;36&nbsp;\u4f4d\u963f\u8332\u6d77\u9ed8\u75c7\u60a3\u8005\u70ba\u53d7\u8a66\u8005\uff0c\u5206\u6210\u63a7\u5236\u7d44\u3001\u651d\u53d62g&nbsp;\u8591\u9ec3\u7d20\u4ee5\u53ca4g&nbsp;\u8591\u9ec3\u7d20\u7684\u4ecb\u5165\u7d44\uff0c\u7e3d\u5171\u4e09\u7d44\uff0c\u524d&nbsp;24&nbsp;\u9031\u70ba\u96d9\u76f2\u5be6\u9a57\uff0c\u5f8c&nbsp;24&nbsp;\u9031\u5247\u70ba\u958b\u653e\u6a19\u7c64\u5be6\u9a57\uff0c\u539f\u672c\u7684\u4ecb\u5165\u7d44\u7e7c\u7e8c\u539f\u672c\u7684\u5291\u91cf\uff0c\u63a7\u5236\u7d44\u5247\u96a8\u6a5f\u5206\u6d3e\u651d\u53d6&nbsp;2g&nbsp;\u53ca4g&nbsp;\u7684\u8591\u9ec3\u7d20\u3002\u672c\u7bc7\u4f7f\u7528\u7684\u8591\u9ec3\u7d20\u70ba&nbsp;Curcumin C3 Complex\u00ae&nbsp;\u81a0\u56ca\uff0c\u5167\u5bb9\u6210\u5206\u542b\u670970%~80%&nbsp;\u8591\u9ec3\u7d20\u300115%~25% demethoxycurcumin\u30012.5%~6.5% bisdemethoxycurcumin\u3002\u7d50\u679c\u767c\u73fe\u4ecb\u5165\u524d\u5f8c\u7121\u8ad6\u662f&nbsp;MMSE\u3001ADAS-Cog score\u3001NPI total score\u3001ADCS-ADL score&nbsp;\u90fd\u6c92\u6709\u986f\u8457\u5dee\u7570\uff0c\u540c\u6a23\u7684\uff0c\u5404\u7a2e\u8840\u6e05\u4e2d\u7684\u751f\u7269\u6307\u6a19\u4e5f\u90fd\u6c92\u6709\u5dee\u7570\u6027\u3002\uff08Ref 22\uff09<br>\u7531\u4e0a\u8ff0\u7814\u7a76\u770b\u8d77\u4f86<strong>\u96d6\u7136\u8591\u9ec3\u7d20\u5728\u7d30\u80de\u6a21\u5f0f\u4e2d\u5df2\u7d93\u8b49\u5be6\u53ef\u4ee5\u6291\u5236\u8a31\u591a\u767c\u708e\u7684\u7d30\u80de\u9014\u5f91\u4ee5\u53ca\u4fc3\u767c\u708e\u7d30\u80de\u6fc0\u7d20\u7684\u751f\u6210\uff0c\u4f46\u7576\u61c9\u7528\u5230\u963f\u8332\u6d77\u9ed8\u75c7\u60a3\u8005\u7684\u4eba\u9ad4\u5be6\u9a57\u7576\u4e2d\uff0c\u4f3c\u4e4e\u90fd\u6c92\u6709\u986f\u8457\u7684\u6548\u679c\u3002\u9019\u53ef\u80fd\u8ddf\u751f\u7269\u53ef\u5229\u7528\u7387\u4ee5\u53ca\u8840\u8166\u969c\u58c1\u7b49\u56e0\u7d20\u6709\u95dc\u3002<\/strong>&nbsp;\u67e5\u770b\u5176\u4ed6\u53ef\u80fd\u529f\u6548&nbsp;<\/li><\/ul>\n\n\n\n<ul><li>12. \u5927\u8178\u6fc0\u8e81\u75c7\u5927\u8178\u6fc0\u8e81\u75c7\u662f\u4e00\u7a2e\u5927\u8178\u7684\u6162\u6027\u75be\u75c5\uff0c\u6700\u5e38\u898b\u7684\u75c7\u72c0\u5305\u62ec\u8178\u7d5e\u75db\u3001\u8179\u75db\u3001\u8178\u8139\u6c23\u3001\u8179\u7009\u53ca\u4fbf\u79d8\u7b49\u7b49\uff0c\u76ee\u524d\u539f\u56e0\u5c1a\u4e0d\u660e\u3002\u00fc &nbsp;&nbsp;\u4e00\u7bc7\u55ae\u76f2\u3001\u96a8\u6a5f\u7684\u524d\u77bb\u6027\u7814\u7a76\u4ee5&nbsp;207&nbsp;\u4f4d\u5927\u8178\u6fc0\u8e81\u75c7\u60a3\u8005\u70ba\u53d7\u8a66\u8005\uff0c\u9032\u884c\u70ba\u671f&nbsp;8&nbsp;\u9031\u7684\u4ecb\u5165\uff0c\u63a7\u5236\u7d44\u651d\u53d6\u5b89\u6170\u5291\uff0c\u5be6\u9a57\u7d44\u5247\u53c8\u5206\u70ba\u4f4e\u5291\u91cf\u53ca\u9ad8\u5291\u91cf\u7d44\uff0c\u5206\u5225\u651d\u53d6&nbsp;72mg&nbsp;\u4ee5\u53ca&nbsp;144mg&nbsp;\u7684\u8591\u9ec3\uff0c\u5176\u4e2d\u6709&nbsp;166&nbsp;\u4f4d\u53d7\u8a66\u8005\u5b8c\u6210\u7814\u7a76\u3002\u7531\u5169\u7a2e\u6e2c\u8a66\u91cf\u8868\u8a55\u4f30\u75c7\u72c0\u6e1b\u7de9\u7684\u60c5\u6cc1\uff0c\u4e00\u500b\u662f&nbsp;ROME II criteria\uff0c\u53e6\u4e00\u500b\u70ba\u5927\u8178\u6fc0\u8e81\u75c7\u7684\u751f\u6d3b\u54c1\u8cea\u554f\u5377\uff0c\u7d50\u679c\u986f\u793a\u4f4e\u5291\u91cf\u53ca\u9ad8\u5291\u91cf\u7d44\u5206\u6578\u5206\u5225\u964d\u4f4e\u4e86&nbsp;22%&nbsp;\u4ee5\u53ca&nbsp;25%\uff0c\u800c\u4ecb\u5165\u5f8c\u5927\u8178\u6fc0\u8e81\u75c7\u7684\u76db\u884c\u7387\u5247\u5206\u5225\u964d\u4f4e\u4e86&nbsp;53%&nbsp;\u4ee5\u53ca&nbsp;60%\uff08Ref 15\uff09\u3002<br>\u7531\u4e0a\u8ff0\u7814\u7a76\u770b\u8d77\u4f86<strong>\u8591\u9ec3\u7d20\u5c0d\u65bc\u5927\u8178\u6fc0\u8e81\u6027\u7684\u63a7\u5236\u6709\u7e7c\u7e8c\u7814\u7a76\u767c\u5c55\u7684\u6f5b\u529b\u3002<\/strong>&nbsp;\u67e5\u770b\u5176\u4ed6\u53ef\u80fd\u529f\u6548&nbsp;<\/li><\/ul>\n\n\n\n<ul><li>13. \u8178\u80c3\u9053\u6f70\u760d\u00fc &nbsp;&nbsp;\u4e00\u7bc7\u6cf0\u570b\u7684\u7b2c\u4e8c\u968e\u6bb5\u81e8\u5e8a\u8a66\u9a57\u4ee5&nbsp;25&nbsp;\u4f4d\u8178\u80c3\u9053\u6f70\u760d\u60a3\u8005\u70ba\u53d7\u8a66\u8005\uff0c\u6f70\u760d\u90e8\u4f4d\u4e3b\u8981\u662f\u5728\u80c3\u4ee5\u53ca\u5341\u4e8c\u6307\u8178\uff0c\u60a3\u90e8\u5927\u5c0f\u76f4\u5f91\u843d\u5728&nbsp;0.5-1.5cm&nbsp;\u4e4b\u9593\u3002\u8591\u9ec3\u7d20\u7684\u5291\u91cf\u70ba\u6bcf\u5929&nbsp;3000mg\uff0c\u5206\u4e94\u6b21\u651d\u53d6\uff0c\u672c\u7bc7\u4f7f\u7528\u7684\u8591\u9ec3\u81a0\u56ca\u662f\u5c07\u8591\u9ec3\u7684\u6839\u90e8\u66ec\u4e7e\u5f8c\u78e8\u7c89\u4ee5\u6bcf\u9846&nbsp;300mg&nbsp;\u7684\u4efd\u91cf\u7528\u81a0\u56ca\u5305\u8986\u30024&nbsp;\u9031\u5f8c\u6709&nbsp;12&nbsp;\u4f4d\u60a3\u8005\u7684\u6f70\u760d\u6d88\u5931\uff0c8&nbsp;\u9031\u5f8c\u6709&nbsp;19&nbsp;\u4f4d\u7684\u6f70\u760d\u6d88\u5931\uff0c12&nbsp;\u9031\u4e4b\u5f8c\u5247\u6709&nbsp;19&nbsp;\u4f4d\u7684\u6f70\u760d\u6d88\u5931\uff0c\u5269\u4e0b\u7684\u5e7e\u4f4d\u5247\u8868\u793a\u75c7\u72c0\u6709\u7de9\u89e3\u7684\u72c0\u6cc1\u3002\uff08Ref 18\uff09<br>\u7531\u4e0a\u8ff0\u7814\u7a76\u770b\u8d77\u4f86<strong>\u77ed\u671f\u9593\u9ad8\u983b\u7387\u5927\u5291\u91cf\u7684\u8591\u9ec3\u7d20\u5c0d\u8178\u80c3\u9053\u6f70\u760d\u6709\u6cbb\u7642\u7684\u6f5b\u529b\u3002<\/strong>&nbsp;&nbsp;\u67e5\u770b\u5176\u4ed6\u53ef\u80fd\u529f\u6548&nbsp;<\/li><\/ul>\n\n\n\n<ul><li>14. \u80c3\u5e7d\u9580\u687f\u83cc\u611f\u67d3\u80c3\u5e7d\u9580\u687f\u83cc\u7684\u611f\u67d3\u76f8\u7576\u5e38\u898b\uff0c\u4e14\u70ba\u8178\u80c3\u9053\u6f70\u760d\u5e38\u898b\u7684\u539f\u56e0\uff0c\u6700\u5e38\u898b\u7684\u6cbb\u7642\u65b9\u5f0f\u5305\u62ec\u8cea\u5b50\u5e6b\u6d66\u6291\u5236\u5291\u4ee5\u53ca\u6297\u751f\u7d20\uff0c\u4f46\u90fd\u6703\u4f34\u96a8\u526f\u4f5c\u7528\u3002\u00fc &nbsp;&nbsp;\u4e00\u7bc7\u7814\u7a76\u4ee5&nbsp;25&nbsp;\u4f4d\u6709\u4f4d\u5e7d\u9580\u687f\u83cc\u611f\u67d3\u4e26\u6709\u6d88\u5316\u4e0d\u826f\u75c7\u72c0\u7684\u75c5\u60a3\u505a\u70ba\u53d7\u8a66\u8005\uff0c\u9023\u7e8c&nbsp;7&nbsp;\u5929\u6bcf\u5929\u651d\u53d6\u5169\u6b21&nbsp;30mg&nbsp;\u7684\u8591\u9ec3\u7d20\u3001100 mg&nbsp;\u7684bovine lactoferrin\u3001600 mg&nbsp;\u7684N-acetylcysteine\u300120 mg&nbsp;\u7684pantoprazole\uff0c\u7d50\u679c\u6709\u53ea&nbsp;3&nbsp;\u4f4d\u6cbb\u7652\uff0c\u5176\u5b83\u7d50\u679c\u5305\u62ec\u4ecb\u5165\u5b8c\u7684&nbsp;2&nbsp;\u500b\u6708\u4e4b\u5f8c\u75c7\u72c0\u6709\u986f\u8457\u6e1b\u8f15\u7684\u60c5\u6cc1\uff1b\u7136\u800c\u8840\u6e05\u4e2d\u7684&nbsp;IgG&nbsp;\u4ee5\u53ca&nbsp;G-17&nbsp;\u5247\u6c92\u6709\u986f\u8457\u964d\u4f4e\uff0c\u56e0\u6b64\u672c\u7bc7\u7814\u7a76\u7684\u7d50\u8ad6\u8a8d\u70ba\u8591\u9ec3\u7d20\u5c0d\u65bc\u6d88\u6ec5\u80c3\u5e7d\u9580\u687f\u83cc\u662f\u7121\u6548\u7684\uff08Ref 19\uff09\u3002\u00fc &nbsp;&nbsp;\u53e6\u4e00\u7bc7\u7814\u7a76\u4ee5&nbsp;36&nbsp;\u4f4d\u6709\u4f4d\u5e7d\u9580\u687f\u83cc\u611f\u67d3\u7684\u60a3\u8005\u70ba\u53d7\u8a66\u8005\uff0c\u4e00\u7d44\u651d\u53d6\u4ee5&nbsp;Omeprazole&nbsp;\u70ba\u4e3b\u7684\u4e09\u7a2e\u85e5\u7269\uff0c\u7642\u7a0b&nbsp;1&nbsp;\u9031\uff1b\u53e6\u4e00\u7d44\u651d\u53d6&nbsp;700mg&nbsp;\u7684\u8591\u9ec3\u7d20\uff0c\u70ba\u671f&nbsp;4&nbsp;\u9031\uff0c\u7d50\u679c\u767c\u73fe\u85e5\u7269\u7d44\u6709&nbsp;78.9%&nbsp;\u53d7\u8a66\u8005\u7684\u80c3\u5e7d\u9580\u687f\u83cc\u88ab\u6d88\u6ec5\uff0c\u800c\u8591\u9ec3\u7d20\u7d44\u53ea\u6709&nbsp;1&nbsp;\u4f4d\u53d7\u8a66\u8005\u6210\u529f\u6cbb\u7642\uff1b\u4ee5\u80c3\u90e8\u5207\u7247\u6e2c\u8a66\u5404\u7a2e\u4fc3\u767c\u708e\u7d30\u80de\u6fc0\u7d20\u5305\u62ec&nbsp;IL-8\u3001IL-1b\u3001TNF-a\u3001COX-2\uff0c\u7d50\u679c\u8591\u9ec3\u7d20\u7d44\u6c92\u6709\u4efb\u4f55\u7d30\u80de\u6fc0\u7d20\u7684\u8868\u73fe\u964d\u4f4e\uff08Ref 20\uff09\u3002<br>\u4e0a\u8ff0\u5169\u7bc7\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c<strong>\u8591\u9ec3\u7d20\u5c0d\u65bc\u80c3\u5e7d\u9580\u687f\u83cc\u7684\u6cbb\u7642\u4f3c\u4e4e\u76ee\u524d\u770b\u8d77\u4f86\u662f\u7121\u6548\u7684\u3002<br><\/strong>&nbsp;\u67e5\u770b\u5176\u4ed6\u53ef\u80fd\u529f\u6548&nbsp;<\/li><\/ul>\n\n\n\n<ul><li>15. \u6297\u764c\u75c7\u5728\u7d30\u80de\u5be6\u9a57\u4ee5\u53ca\u52d5\u7269\u5be6\u9a57\u7576\u4e2d\uff0c\u767c\u73fe\u8591\u9ec3\u7d20\u53ef\u4ee5\u9810\u9632\u764c\u75c7\u7684\u9032\u5c55\u4e3b\u8981\u662f\u900f\u904e\u5169\u500b\u6a5f\u5236\uff1a<strong>\u5f71\u97ff\u8840\u7ba1\u65b0\u751f\u4ee5\u53ca\u816b\u7624\u751f\u9577<\/strong>\u3002\u800c\u8591\u9ec3\u7d20\u6291\u5236\u816b\u7624\u8840\u7ba1\u65b0\u751f\u5247\u662f\u900f\u904e\u4ee5\u4e0b\u591a\u500b\u6a5f\u5236\uff1a\u8abf\u7bc0&nbsp;NF-kB\u3001AP-1\u3001EGR-1&nbsp;\u7684\u8868\u73fe\uff0c\u6e1b\u5f31\u80f0\u81df\u764c\u3001\u982d\u9838\u764c\u7d30\u80de\u682a\u7684&nbsp;IL-8&nbsp;\u8868\u73fe\uff0c\u907f\u514d\u8840\u7ba1\u5167\u76ae\u751f\u9577\u56e0\u5b50\uff08VEGF\uff09\u7684\u5408\u6210\u3001\u6291\u5236\u7531&nbsp;NO&nbsp;\u4ee5\u53ca&nbsp;iNOS&nbsp;\u8abf\u7bc0\u7684\u8840\u7ba1\u65b0\u751f\u3001\u6291\u5236&nbsp;COX-2&nbsp;\u4ee5\u53ca&nbsp;5-LOX\u3001\u76f4\u63a5\u6e1b\u5c11\u8840\u7ba1\u5167\u76ae\u751f\u9577\u56e0\u5b50\u4ee5\u53ca\u57fa\u790e\u7e96\u7dad\u6bcd\u7d30\u80de\u751f\u9577\u56e0\u5b50\u7684\u5f62\u6210\u7b49\u7b49\u3002\u7d30\u80de\u5be6\u9a57\u4e2d\u5247\u767c\u73fe\u8591\u9ec3\u7d20\u6703\u4fc3\u9032\u5404\u7a2e\u52d5\u7269\u53ca\u4eba\u985e\u7684\u764c\u75c7\u7d30\u80de\u682a\u6b7b\u4ea1\uff0c\u5305\u62ec\u767d\u8840\u75c5\u3001\u9ed1\u8272\u7d20\u7624\u3001\u4e73\u764c\u3001\u5927\u8178\u764c\u3001\u5375\u5de2\u764c\u3001\u814e\u81df\u764c\u3001\u80ba\u764c\u4ee5\u53ca\u809d\u764c\u7d30\u80de\uff08Ref 1\uff09\u3002\u00fc &nbsp;&nbsp;\u4e00\u7bc7\u4ee5&nbsp;15&nbsp;\u4f4d<strong>\u5927\u8178\u76f4\u8178\u764c<\/strong>\u60a3\u8005\u70ba\u53d7\u8a66\u8005\u7684\u7814\u7a76\uff0c\u8b93\u75c5\u4eba\u5728\u65e9\u6668\u7a7a\u8179\u81f3\u5c11&nbsp;2&nbsp;\u5c0f\u6642\u7684\u60c5\u6cc1\u4e0b\u651d\u53d6\u542b\u6709&nbsp;0.45~3.6g&nbsp;\u8591\u9ec3\u7d20\u7684\u81a0\u56ca\uff0c\u5be6\u9a57\u6301\u7e8c\u9032\u884c\u81f3\u75c5\u60c5\u60e1\u5316\u6216\u53d7\u8a66\u8005\u9000\u51fa\u5be6\u9a57\uff0c\u6642\u9593\u6700\u9577\u7684\u53d7\u8a66\u8005\u7dad\u6301\u4e86&nbsp;4&nbsp;\u500b\u6708\u3002\u6b64\u7814\u7a76\u7d50\u679c\u767c\u73fe\u5728&nbsp;3.6g&nbsp;\u7684\u7d44\u5225\u8840\u6db2\u4e2d\u7684&nbsp;PGE2&nbsp;\u5728\u4ecb\u5165\u7b2c&nbsp;1&nbsp;\u5929\u53ca\u7b2c&nbsp;29&nbsp;\u5929\u6bd4\u521d\u59cb\u6e1b\u5c11\u4e86&nbsp;62%&nbsp;\u4ee5\u53ca&nbsp;57%\u3002\u5728&nbsp;3.6g&nbsp;\u7d44\u5225\u7684\u4e09\u4f4d\u53d7\u8a66\u8005\u5728\u651d\u53d6\u8591\u9ec3\u81a0\u56ca\u5f8c\u7684&nbsp;1&nbsp;\u5c0f\u6642\u5f8c\u8840\u6db2\u4e2d\u53ef\u5075\u6e2c\u5230&nbsp;11.1nmol\/L&nbsp;\u7684\u8591\u9ec3\u7d20\u3002\u7531\u65bc\u6b64<strong>\u7814\u7a76\u53d7\u8a66\u8005\u4eba\u6578\u5f88\u5c11\uff0c\u56e0\u6b64\u7d50\u679c\u5c1a\u5f85\u66f4\u5927\u578b\u7684\u7814\u7a76\u4f86\u518d\u6b21\u8a55\u4f30<\/strong>\uff08Ref 10\uff09\u3002\u00fc &nbsp;&nbsp;\u53e6\u4e00\u7bc7\u96a8\u6a5f\u5206\u7d44\u7684\u96d9\u76f2\u5be6\u9a57\u5247\u4ee5&nbsp;126&nbsp;\u4f4d\u8a3a\u65b7\u70ba\u5927\u8178\u76f4\u8178\u764c\u60a3\u8005\u70ba\u53d7\u8a66\u8005\uff0c\u5206\u70ba\u63a7\u5236\u7d44\u53ca\u651d\u53d6\u8591\u9ec3\u81a0\u56ca\u7684\u5be6\u9a57\u7d44\uff0c\u5be6\u9a57\u7d44\u6bcf\u5929\u651d\u53d6&nbsp;3&nbsp;\u6b21\u542b\u6709&nbsp;360mg&nbsp;\u8591\u9ec3\u7684\u81a0\u56ca\uff1b\u63a7\u5236\u7d44\u5247\u662f\u5403&nbsp;3&nbsp;\u6b21\u5b89\u6170\u5291\uff0c\u4ecb\u5165\u6642\u9593\u76f4\u5230\u75c5\u4eba\u63a5\u53d7\u624b\u8853\uff0c\u56e0\u6b64\u6bcf\u4f4d\u53d7\u8a66\u8005\u4ecb\u5165\u6642\u9593\u4e0d\u540c\uff0c\u5927\u7d04\u843d\u5728&nbsp;10-30&nbsp;\u5929\u4e4b\u9593\u3002\u7d50\u679c\u767c\u73fe\u5be6\u9a57\u7d44\u7684\u75c5\u4eba\u6bd4\u8d77\u63a7\u5236\u7d44\u9ad4\u91cd\u6709\u986f\u8457\u4e0a\u5347\u7684\u60c5\u5f62\uff0c\u7531\u65bc\u9ad4\u91cd\u8b8a\u5316\u8207\u5176\u4ed6\u8a31\u591a\u56e0\u7d20\u6709\u95dc\uff0c\u7814\u7a76\u8005\u5b89\u6392\u71df\u990a\u5e2b\u5e6b\u5fd9\u8a08\u7b97\u75c5\u4eba\u651d\u53d6\u7684\u71b1\u91cf\uff0c\u767c\u73fe\u5169\u7d44\u4e4b\u9593\u6c92\u6709\u986f\u8457\u5dee\u7570\uff0c\u800c\u6392\u4fbf\u72c0\u6cc1\u5247\u662f\u63a7\u5236\u7d44\u53ca\u5be6\u9a57\u7d44\u5206\u5225\u5404\u6709&nbsp;8&nbsp;\u4eba\u53ca&nbsp;10&nbsp;\u4eba\u767c\u751f\u8179\u7009\u60c5\u6cc1\uff1b\u6b64\u5916\uff0c\u5be6\u9a57\u7d44\u75c5\u4eba\u8840\u6e05\u4e2d\u7684&nbsp;TNF-a&nbsp;\u6bd4\u8d77\u521d\u59cb\u503c\u4e5f\u6709\u986f\u8457\u4e0b\u964d\u7684\u60c5\u6cc1\uff0c\u63a7\u5236\u7d44\u5247\u6c92\u6709\u6b64\u73fe\u8c61\uff1b\u7814\u7a76\u8005\u4e5f\u4f7f\u7528&nbsp;TUNEL&nbsp;\u67d3\u8272\u6cd5\u4ee5\u53ca\u89c0\u5bdf&nbsp;DNA&nbsp;\u788e\u7247\u4f86\u6bd4\u8f03\u4ecb\u5165\u524d\u5f8c\u5927\u8178\u76f4\u8178\u764c\u7d44\u7e54\u7576\u4e2d\u7d30\u80de\u51cb\u4ea1\u7684\u60c5\u6cc1\uff0c\u7d50\u679c\u986f\u793a\u5be6\u9a57\u7d44\u5728\u4ee5\u8591\u9ec3\u4ecb\u5165\u5f8c\u764c\u7d44\u7e54\u7d30\u80de\u51cb\u4ea1\u7684\u72c0\u6cc1\u660e\u986f\u63d0\u5347\uff0c\u63a7\u5236\u7d44\u5247\u6c92\u6709\u5dee\u7570\uff1b\u4e14\u5728\u5be6\u9a57\u7d44\u9084\u89c0\u5bdf\u5230\u6291\u5236\u764c\u7d30\u80de\u589e\u751f\u7684&nbsp;p53&nbsp;\u7684\u57fa\u56e0\u8868\u73fe\u4e0a\u5347\u7684\u60c5\u6cc1\uff08Ref 11\uff09\u3002\u00fc &nbsp;&nbsp;\u4e00\u7bc7\u4ee5&nbsp;25&nbsp;\u4f4d\u80f0\u81df\u764c\u60a3\u8005\u70ba\u53d7\u8a66\u8005\u7684\u7814\u7a76\u5247\u8b93\u75c5\u4eba\u6bcf\u5929\u651d\u53d6&nbsp;8g&nbsp;\u7684\u985e\u8591\u9ec3\u7d20\uff0c\u5176\u4e2d\u7684&nbsp;7.2g&nbsp;\u70ba\u8591\u9ec3\u7d20\uff0c\u4ecb\u5165\u6642\u9593\u76f4\u5230\u75c5\u60c5\u51fa\u73fe\u9032\u5c55\u70ba\u6b62\u3002\u8207\u5176\u4ed6\u591a\u7bc7\u7814\u7a76\u7d50\u679c\u76f8\u4f3c\uff0c\u6b64\u7bc7\u7814\u7a76\u767c\u73fe\u5927\u90e8\u5206\u53ef\u5728\u8840\u6db2\u4e2d\u88ab\u5075\u6e2c\u5230\u7684\u8591\u9ec3\u7686\u662f\u8207\u8461\u8404\u91a3\u919b\u9178\uff08glucuronide\uff09\u4ee5\u53ca\u786b\u9178\u9e7d\uff08sulfate\uff09\u7d50\u5408\u7684\u5f62\u5f0f\uff0c\u4e14\u91cf\u6975\u5c11\uff0c\u518d\u6b21\u986f\u793a\u4e86\u8591\u9ec3\u7684\u4f4e\u751f\u7269\u5229\u7528\u7387\uff1b\u53e6\u5916\u767c\u73fe\u60a3\u8005\u5468\u570d\u8840\u55ae\u6838\u7d30\u80de\uff08peripheral blood mononuclear cells\uff09\u4e2d\u7684&nbsp;NF-kB\u3001COX-2&nbsp;\u4ee5\u53ca&nbsp;pSTAT3&nbsp;\u8868\u73fe\u6709\u4e0b\u964d\u7684\u72c0\u6cc1\uff08Ref 12\uff09\u3002\u00fc &nbsp;&nbsp;\u5169\u7bc7\u7814\u7a76\u540c\u6a23\u8b93\u80f0\u81df\u764c\u53d7\u8a66\u8005\u651d\u53d6&nbsp;8g&nbsp;\u8591\u9ec3\u7d20\u5408\u4f75\u6297\u764c\u85e5\u7269&nbsp;Gemcitabine&nbsp;\u4f7f\u7528\uff0c\u7b2c\u4e00\u7bc7\u7814\u7a76\u7684&nbsp;17&nbsp;\u4f4d\u53d7\u8a66\u8005\u7576\u4e2d\u6709&nbsp;5&nbsp;\u4f4d\u56e0\u70ba\u51fa\u73fe\u96e3\u4ee5\u5fcd\u53d7\u7684\u8179\u75db\u53ca\u8179\u8139\u800c\u505c\u6b62\u5be6\u9a57\uff0c\u53e6\u5916&nbsp;2&nbsp;\u4f4d\u56e0\u70ba\u51fa\u73fe\u8179\u90e8\u75c7\u72c0\u800c\u5c07\u8591\u9ec3\u7d20\u5291\u91cf\u6e1b\u70ba&nbsp;4g\uff0c\u56e0\u6b64\u7b2c\u4e00\u7bc7\u7814\u7a76\u7684\u7d50\u8ad6\u8a8d\u70ba&nbsp;8&nbsp;\u516c\u514b\u7684\u8591\u9ec3\u7d20\u5c0d\u5408\u4f75&nbsp;Gemcitabine&nbsp;\u7684\u6cbb\u7642\u800c\u8a00\u5291\u91cf\u53ef\u80fd\u904e\u9ad8\uff1b\u7b2c\u4e8c\u7bc7\u7814\u7a76\u7684&nbsp;21&nbsp;\u4f4d\u53d7\u8a66\u8005\u5247\u662f\u90fd\u6c92\u6709\u51fa\u73fe\u6bd2\u6027\u53cd\u61c9\uff0c\u4ee5\u8591\u9ec3\u7d20\u4ecb\u5165\u4e4b\u5f8c\u7684\u5e73\u5747\u5b58\u6d3b\u6642\u9593\u70ba&nbsp;161&nbsp;\u5929\uff0c\u4e00\u5e74\u4e4b\u5f8c\u7684\u5b58\u6d3b\u7387\u5247\u70ba&nbsp;19%\uff0c\u5176\u4e2d&nbsp;5&nbsp;\u4f4d\u53d7\u8a66\u8005\u8840\u6f3f\u4e2d\u7684\u8591\u9ec3\u7d20\u6fc3\u5ea6\u5927\u7d04\u843d\u5728&nbsp;29~412 ng\/mL&nbsp;\u4e4b\u9593\uff08Ref 9\u3001Ref 32\uff09\u3002<br>\u7531\u4e0a\u8ff0\u5be6\u9a57\uff0c\u53ef\u63a8\u65b7<strong>\u9ad8\u5291\u91cf\u7684\u8591\u9ec3\u7d20\u5c0d\u65bc\u764c\u75c7\u7684\u6cbb\u7642\u53ef\u80fd\u6709\u767c\u5c55\u6f5b\u529b\u3002<\/strong>&nbsp;\u67e5\u770b\u5176\u4ed6\u53ef\u80fd\u529f\u6548&nbsp;<\/li><\/ul>\n\n\n\n<ul><li>16. \u95dc\u7bc0\u708e\u95dc\u7bc0\u708e\u60a3\u8005\u7684\u4fc3\u767c\u708e\u7d30\u80de\u6fc0\u7d20\u53ca\u9175\u7d20\u901a\u5e38\u6703\u6709\u8abf\u7bc0\u7570\u5e38\u7684\u72c0\u6cc1\uff0c\u5176\u4e2d\u5305\u62ec\u4e86&nbsp;TNF-a\u3001IL-1b\uff0c\u4ee5\u53ca\u8abf\u7bc0\u524d\u5217\u817a\u7d20\uff08prostaglandins\uff09\u53ca\u767d\u4e09\u70ef\u7d20\uff08leukotrienes\uff09\u7684&nbsp;COX-2&nbsp;\u548c\u8102\u8cea\u6c27\u5316\u9176\uff0c\u56e0\u6b64\u5177\u6709\u6297\u767c\u708e\u80fd\u529b\u7684\u8591\u9ec3\u7d20\u4fbf\u88ab\u61c9\u7528\u5728\u95dc\u7bc0\u708e\u7684\u6cbb\u7642\u4e2d\u3002\u00fc &nbsp;&nbsp;\u4e00\u7bc7\u524d\u77bb\u6027\u7814\u7a76\u4ee5&nbsp;45&nbsp;\u4f4d\u95dc\u7bc0\u708e\u60a3\u8005\u505a\u70ba\u53d7\u8a66\u8005\u5206\u6210\u4e09\u7d44\uff0c\u5206\u5225\u651d\u53d6&nbsp;500mg&nbsp;\u8591\u9ec3\u7d20\u300150mg Diclofenac sodium\u3001\u6216\u5169\u8005\u5408\u4f75\u4f7f\u7528\u3002\u7b2c\u4e00\u500b\u5be6\u9a57\u7684\u4e3b\u8981\u7d42\u9ede\u70ba&nbsp;Disease Activity Score (DAS)&nbsp;\u7684\u5206\u6578\u4e0b\u964d\uff0c\u7b2c\u4e8c\u7d42\u9ede\u5247\u70ba&nbsp;American College of Rheumatology (ACR) criteria&nbsp;\u4e0b\u964d\u3002\u4e09\u7d44\u7684&nbsp;DAS&nbsp;\u4ee5\u53ca&nbsp;ACR&nbsp;\u7686\u6709\u986f\u8457\u4e0b\u964d\uff0c\u6709\u8da3\u7684\u662f\uff0c\u55ae\u7368\u651d\u53d6\u8591\u9ec3\u7d20\u7684\u7d44\u5225\u5206\u6578\u4e0b\u964d\u7684\u6bd4\u7387\u6700\u9ad8\u3002\u672c\u7bc7\u4f7f\u7528\u7684\u8591\u9ec3\u7d20\u70ba&nbsp;BCM-95\uff0c\u5c07\u8591\u9ec3\u7d20\u8207\u8591\u9ec3\u4e2d\u5176\u4ed6\u975e\u6d3b\u6027\u6210\u5206\u7d50\u5408\uff0c\u85c9\u4ee5\u63d0\u9ad8\u751f\u7269\u5229\u7528\u7387\uff08Ref 16\uff09\u3002\u00fc &nbsp;&nbsp;\u53e6\u4e00\u7bc7\u7814\u7a76\u4ee5&nbsp;100&nbsp;\u4f4d\u95dc\u7bc0\u708e\u60a3\u8005\u70ba\u53d7\u8a66\u8005\uff0c\u5206\u70ba\u63a7\u5236\u7d44\u53ca\u5be6\u9a57\u7d44\uff0c\u5be6\u9a57\u7d44\u651d\u53d6\u8207\u78f7\u8102\u91af\u81bd\u9e7c\u7d50\u5408\u7684\u8591\u9ec3\u7d20&nbsp;Meriva\uff0c\u65e9\u665a\u5404\u541e\u4e00\u9846&nbsp;500mg&nbsp;\u7684\u9320\u5291\uff0c\u7e3d\u5171\u542b\u6709&nbsp;200mg&nbsp;\u7684\u8591\u9ec3\u7d20\u30028&nbsp;\u500b\u6708\u4e4b\u5f8c&nbsp;WOMAC score\u5206\u6578\u4e0b\u964d\u4e86&nbsp;50%\uff0c\u8dd1\u6b65\u6a5f\u904b\u52d5\u6e2c\u8a66\u7d50\u679c\u5be6\u9a57\u7d44\u6bd4\u63a7\u5236\u7d44\u512a\u4e86\u5c07\u8fd1&nbsp;3&nbsp;\u500d\uff1b\u5be6\u9a57\u7d44\u53d7\u8a66\u8005\u8840\u6e05\u4e2d\u7684\u4fc3\u767c\u708e\u751f\u7269\u6307\u6a19\u5305\u62ec&nbsp;IL-1b\u3001IL-6\u3001soluble CD40 ligand\u3001soluble vascular cell adhesion molecule-1&nbsp;\u548c\u7d05\u8840\u7403\u6c89\u964d\u7387\u4e5f\u90fd\u6709\u986f\u8457\u4e0b\u964d\u7684\u60c5\u5f62\u3002\u6b64\u5916\uff0c\u6709\u60a3\u8005\u8868\u793a\u651d\u53d6&nbsp;Meriva&nbsp;\u4e4b\u5f8c\uff0c\u5403&nbsp;NSAID&nbsp;\u85e5\u7269\u6216\u5176\u4ed6\u6b62\u75db\u85e5\u7684\u526f\u4f5c\u7528\u6709\u6e1b\u8f15\u7684\u73fe\u8c61\uff08Ref 17\uff09\u3002<br>\u7531\u4e0a\u8ff0\u7814\u7a76\uff0c<strong>\u9ad8\u5291\u91cf\u7684\u8591\u9ec3\u7684\u6297\u767c\u708e\u80fd\u529b\uff0c\u5c0d\u65bc\u95dc\u7bc0\u708e\u53ef\u80fd\u7522\u751f\u7de9\u89e3\u7684\u4f5c\u7528\u3002<\/strong>&nbsp;\u67e5\u770b\u5176\u4ed6\u53ef\u80fd\u529f\u6548&nbsp;<\/li><\/ul>\n\n\n\n<ul><li>17. \u6182\u9b31\u75c7\u8591\u9ec3\u7d20\u4e4b\u6240\u4ee5\u6703\u5b78\u8005\u8a8d\u70ba\u53ef\u80fd\u5177\u6709\u6297\u6182\u9b31\u6548\u679c\uff0c\u9664\u4e86\u56e0\u70ba\u5b83\u672c\u8eab\u5177\u6709\u6297\u767c\u708e\u3001\u6297\u6c27\u5316\u80fd\u529b\u4e4b\u5916\uff0c\u4e5f\u56e0\u70ba\u8591\u9ec3\u7d20\u5177\u6709\u5176\u4ed6\u8207\u6182\u9b31\u75c7\u75c5\u56e0\u76f8\u95dc\u7684\u751f\u7269\u6548\u61c9\uff0c\u5305\u62ec\uff1a\u6291\u5236\u55ae\u80fa\u6c27\u5316\u9176\u6d3b\u6027\u3001\u6703\u5f71\u97ff\u8840\u6e05\u7d20\u53ca\u591a\u5df4\u80fa\u7684\u91cb\u653e\u3001\u8abf\u7bc0\u4e0b\u8996\u4e18\u2013\u8166\u5782\u817a\u2013\u814e\u4e0a\u817a\u8ef8\uff08hypothalamic\u2013pituitary\u2013adrenal axis\uff09\u3001\u8abf\u7bc0\u795e\u7d93\u71df\u990a\u56e0\u5b50\uff08neurotrophic factors\uff09\u3001\u6d77\u99ac\u8ff4\u7684\u795e\u7d93\u751f\u6210\u4ee5\u53ca\u795e\u7d93\u53ef\u5851\u6027\uff08Ref 45\uff09\u3002\u00fc &nbsp; \u4e00\u7bc7&nbsp;2017&nbsp;\u5e74&nbsp;6&nbsp;\u6708\u624d\u525b\u767c\u8868\u7684\u6574\u5408\u5206\u6790\uff08meta-analysis\uff09\u7be9\u9078\u4e86\u5169\u5343\u591a\u7bc7\u8591\u9ec3\u7d20\u8207\u6182\u9b31\u75c7\u4ee5\u53ca\u81ea\u6bba\u76f8\u95dc\u7684\u8ad6\u6587\uff0c\u6392\u9664\u4e86\u975e\u4eba\u9ad4\u8a66\u9a57\u7684\u7814\u7a76\u3001\u975e\u96a8\u6a5f\u5206\u7d44\u6216\u6c92\u6709\u63a7\u5236\u7d44\u7684\u7814\u7a76\u3001\u8207\u6291\u9b31\uff08depressive disorder\uff09\u4e0d\u76f8\u95dc\u7684\u7814\u7a76\uff0c\u6700\u5f8c\u7559\u4e0b\u516d\u7bc7\u7814\u7a76\u505a\u5206\u6790\uff0c\u53d7\u8a66\u8005\u4eba\u6578\u7e3d\u5171\u70ba&nbsp;377&nbsp;\u4f4d\u3002\u516d\u7bc7\u7814\u7a76\u4e2d\u4f7f\u7528\u7684\u8591\u9ec3\u7d20\u5291\u91cf\u6709\u4e94\u7bc7\u70ba\u6bcf\u5929&nbsp;1g&nbsp;\uff0c\u4e00\u7bc7\u70ba\u6bcf\u5929&nbsp;500mg\uff0c\u5169\u7bc7\u4f7f\u7528\u7684\u8591\u9ec3\u7d20\u70ba&nbsp;BCM-95\uff0c\u5176\u4e2d\u4e09\u7bc7\u9664\u4e86\u5c07\u9ec3\u7d20\u5916\u540c\u6642\u6709\u6dfb\u52a0&nbsp;10&nbsp;\u6216&nbsp;50mg&nbsp;\u7684\u80e1\u6912\u9e7c\uff0c\u4ecb\u5165\u6642\u9593\u5f9e&nbsp;4&nbsp;\u9031\u81f3&nbsp;6&nbsp;\u9031\u4e0d\u7b49\u3002\u7d71\u8a08\u5206\u6790\u7d50\u679c\u986f\u793a\uff0c\u4ee5\u6f22\u5f0f\u6182\u9b31\u91cf\u8868\u8a55\u4f30\u6182\u9b31\u7a0b\u5ea6\uff0c\u767c\u73fe\u651d\u53d6\u8591\u9ec3\u7d20\u7684\u5be6\u9a57\u7d44\u6bd4\u63a7\u5236\u7d44\u7684\u6182\u9b31\u75c7\u72c0\u986f\u8457\u5730\u6539\u5584\uff0c\u4e14\u5728\u6b64\u516d\u7bc7\u7814\u7a76\u7576\u4e2d\u90fd\u6c92\u6709\u51fa\u73fe\u526f\u4f5c\u7528\uff0c\u5176\u4e2d\u4e09\u7bc7\u7814\u7a76\u540c\u6642\u767c\u73fe\u8591\u9ec3\u5177\u6709\u986f\u8457\u7684\u6297\u7126\u616e\u6548\u679c\u3002<br>\u4f46\u7531\u65bc<strong>\u76ee\u524d\u9019\u516d\u7bc7\u7814\u7a76\u7684\u4ecb\u5165\u6642\u9593\u4e0d\u9577\uff0c\u53d7\u8a66\u8005\u4eba\u6578\u4e5f\u4e0d\u5920\u591a\uff0c\u56e0\u6b64\u8591\u9ec3\u7684\u6297\u6182\u9b31\u6548\u679c\u9084\u9700\u8981\u5f8c\u7e8c\u66f4\u591a\u7684\u7814\u7a76\u8005\u4f86\u8b49\u5be6<\/strong>\uff08Ref 44\uff09\u3002<\/li><\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u8591\u9ec3\u7d20\uff08Curcumin\uff09\u53ef\u4ee5\u8aaa\u662f\u8fd1\u5e74\u4f86\u6700\u591a\u7814\u7a76\u8005\u8da8\u4e4b\u82e5\u9da9\u505a\u7814\u7a76\u7684\u7269\u8cea\u4e4b\u4e00\uff0c\u5b83\u662f\u8591\u9ec3\uff08Curmuma&nbsp;longa&nbsp;L.\uff09\u4e2d\u542b\u6709\u7684\u6210\u5206\u3002\u5728\u9019\u908a\u6211\u5011\u5148\u8aaa\u4e00\u90e8\u5206\u7d50\u8ad6\uff1a\u82e5\u4eba\u9ad4\u5438\u6536\u4e86\u8db3\u5920\u5291\u91cf\u7684\u8591\u9ec3\u7d20\uff0c\u78ba\u5be6\u5728\u67d0\u4e9b\u554f\u984c\u5177\u6709\u4e00\u4e9b\u529f\u6548\uff0c\u4f46\u7db2\u8def\u4e0a\u4f60\u5982\u679c\u770b\u5230\u300c\u8591\u9ec3\u529f\u80fd\u6253\u6557\u897f\u85e5\u300d\u9019\u985e\u7684\u8ad6\u9ede\uff0c\u4f60\u5c31\u5148\u7b11\u7b11\u5c31\u7b97\u4e86\uff0c\u5be6\u969b\u4e0a\u76ee\u524d\u7684\u7814\u7a76\u8ddd\u96e2\u300c\u6253\u6557\u897f\u85e5\u300d\u9084\u6709\u5f88\u5927\u7684\u8ddd\u96e2\u554a\uff5e 1. \u6297\u767c\u708e\u5404\u7a2e\u5206\u5b50\u7814\u7a76\u5df2\u7d93\u8b49\u5be6\u8591\u9ec3\u7d20\u53ef\u4ee5\u6291\u5236\u4fc3\u767c\u708e\u56e0\u5b50\uff0c\u5728\u4ee5\u8102\u591a\u91a3\u523a\u6fc0\u4eba\u985e\u8840\u6db2\u7684\u5be6\u9a57\u6a21\u5f0f\u4e2d\uff0c\u767c\u73fe\u8591\u9ec3\u7d20\u53ef\u4ee5\u900f\u904e\u6291\u5236&nbsp;PGE2&nbsp;\u5408\u6210\u9176&nbsp;1&nbsp;\u7684\u6d3b\u6027\u4f86\u6e1b\u5c11\u4fc3\u767c\u708e\u7d30\u80de\u6fc0\u7d20&nbsp;PGE2&nbsp;\u7684\u751f\u5408\u6210\uff08Ref 33\uff09\uff1b\u5728\u5c0f\u9f20\u5de8\u566c\u7d30\u80de\u4ee5\u53ca\u4eba\u985e\u5927\u8178\u764c\u7d30\u80de\u6a21\u5f0f\u4e2d\uff0c\u540c\u6a23\u8b49\u5be6\u4e86\u8591\u9ec3\u7d20\u53ef\u4ee5\u6291\u5236\u7531\u8102\u591a\u91a3\u6240\u8a98\u767c\u7684&nbsp;COX-2&nbsp;\u8868\u73fe\uff0c\u9032\u800c\u53ef\u80fd\u6e1b\u5c11&nbsp;PGE2&nbsp;\u7684\u751f\u6210\uff08Ref 35\uff09\uff1b\u5728\u5b50\u5bae\u9838\u764c\u7d30\u80de\u682a\u7684\u5be6\u9a57\u4e2d\u767c\u73fe\u8591\u9ec3\u7d20\u6703\u4fc3\u9032\u764c\u7d30\u80de\u7684\u51cb\u4ea1\uff0c\u6b64\u5916\u4e5f\u6703\u6291\u5236&nbsp;AP-1&nbsp;\u4ee5\u53ca&nbsp;NF-kB&nbsp;\u7684\u8868\u73fe\uff08Ref 34\uff09\uff1b\u53e6\u5916\u4e00\u7bc7\u5c0f\u9f20\u7d30\u80de\u682a\u7684\u5be6\u9a57\u5247\u767c\u73fe\u8591\u9ec3\u7d20\u53ef\u4ee5\u6291\u5236\u4fc3\u767c\u708e\u7d30\u80de\u6fc0\u7d20IL-18\uff08Ref 36\uff09\u3002\u8591\u9ec3\u7d20\u88ab\u767c\u73fe\u53ef\u900f\u904e\u6291\u5236\u7279\u5b9a\u9175\u7d20\u7684\u6d3b\u6027\uff0c\u4f86\u964d\u4f4e\u767c\u708e\u7d30\u80de\u7522\u751f\u7684\u767c\u708e\u53cd\u61c9\u3002\u4f46\u9019\u4e9b\u7814\u7a76\u7d50\u679c\u548c\u5be6\u969b\u4eba\u9ad4\u5be6\u9a57\u9084\u6709\u8ddd\u96e2\u3002&nbsp;\u67e5\u770b\u5176\u4ed6\u53ef\u80fd\u529f\u6548&nbsp; 2. \u6297\u6c27\u5316\u6c27\u5316\u4e00\u822c\u4f86\u8aaa\u88ab\u8a8d\u70ba\u548c\u4eba\u9ad4\u8001\u5316\u6709\u95dc\uff0c\u56e0\u6b64\u6297\u6c27\u5316\u80fd\u529b\u901a\u5e38\u88ab\u8a8d\u70ba\u662f\u4e00\u7a2e\u6297\u8001\u5316\u80fd\u529b\u3002\u5728\u7d30\u80de\u5be6\u9a57\u4e2d\u767c\u73fe\u8591\u9ec3\u7d20\u5177\u6709\u900f\u904e\u4fc3\u9032\u8840\u7d05\u7d20\u4e2d\u7684\u7279\u5b9a\u9175\u7d20\u8868\u73fe\uff0c\u7522\u751f\u4fdd\u8b77\u7d30\u80de\u62b5\u6297\u6c27\u5316\u58d3\u529b\u7684\u529f\u80fd\uff08Ref &nbsp;37\uff09\uff1b\u5728\u53e6\u4e00\u500b\u5c0f\u9f20\u7d30\u80de\u7684\u5be6\u9a57\u4e2d\uff0c\u4e5f\u767c\u73fe\u8591\u9ec3\u7d20\u6709\u6297\u6c27\u5316\u7684\u80fd\u529b\uff08Ref 38\uff09\u3002\u5728\u4e00\u7bc7\u7cd6\u5c3f\u75c5\u5c0f\u9f20\u7684\u52d5\u7269\u5be6\u9a57\u4e2d\u5247\u767c\u73fe\uff0c\u651d\u53d6\u8591\u9ec3\u7d20\u7684\u5c0f\u9f20\u8840\u6e05\u4e2d\u8d85\u6c27\u5316\u7269\u6b67\u5316\u9176\uff08SOD\uff09\u7684\u542b\u91cf\u6bd4\u8f03\u591a\uff0cSOD&nbsp;\u662f\u4e00\u7a2e\u6297\u6c27\u5316\u7269\u3002\u56e0\u6b64\u5728\u7d30\u80de\u5be6\u9a57\u53ca\u52d5\u7269\u5be6\u9a57\u4e2d\uff0c\u8591\u9ec3\u88ab\u8a8d\u70ba\u5177\u6709\u4e00\u5b9a\u7684\u6297\u6c27\u5316\u80fd\u529b\u3002&nbsp;\u67e5\u770b\u5176\u4ed6\u53ef\u80fd\u529f\u6548&nbsp; 3. \u9810\u9632\u5fc3\u8840\u7ba1\u75be\u75c5\u56e0\u70ba\u767c\u708e\u662f\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u5371\u96aa\u56e0\u5b50\u4e4b\u4e00\uff0c\u8591\u9ec3\u7d20\u7684\u6297\u767c\u708e\u80fd\u529b\u5c31\u5728\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u6cbb\u7642\u4e0a\u626e\u6f14\u4e86\u91cd\u8981\u89d2\u8272\u3002\u67d0\u7bc7\u5c0f\u9f20\u5be6\u9a57\u767c\u73fe\u7d66\u4e88\u6709\u9ad8\u8840\u58d3\u6027\u5fc3\u81df\u75be\u75c5\u7684\u5c0f\u9f20\u6bcf\u516c\u65a4\u9ad4\u91cd&nbsp;50mg&nbsp;\u7684\u8591\u9ec3\u7d20\u53ef\u4ee5\u9810\u9632\u5fc3\u81df\u8870\u7aed\u3002\uff08Ref 23\uff09\u9019\u662f\u4e00\u7bc7\u52d5\u7269\u5be6\u9a57\uff0c\u5be6\u969b\u5728\u4eba\u9ad4\u5be6\u9a57\u662f\u5426\u80fd\u767c\u63ee\u4f5c\u7528\u7684\u8b8a\u6578\u4ecd\u591a\u3002&nbsp;\u67e5\u770b\u5176\u4ed6\u53ef\u80fd\u529f\u6548&nbsp; 4. \u964d\u4f4e\u8840\u4e2d\u81bd\u56fa\u9187\u00fc &nbsp;&nbsp;\u4e00\u7bc7\u7814\u7a76\u4ee5&nbsp;33&nbsp;\u4f4d\u6709\u51a0\u72c0\u52d5\u8108\u75be\u75c5\u7684\u75c5\u4eba\u70ba\u53d7\u8a66\u8005\uff0c\u5c07\u5176\u5206\u70ba\u63a7\u5236\u7d44\u4ee5\u53ca\u8591\u9ec3\u7d20\u7d44\u9032\u884c\u70ba\u671f&nbsp;8&nbsp;\u9031\u7684\u5be6\u9a57\uff0c\u63a7\u5236\u7d44\u6bcf\u5929\u5403\u56db\u6b21\u5b89\u6170\u5291\uff1b\u8591\u9ec3\u7d20\u7d44\u5247\u6bcf\u5929\u5403\u56db\u6b21\u542b&nbsp;500mg&nbsp;\u8591\u9ec3\u7d20\u7684\u81a0\u56ca\uff0c\u672c\u7bc7\u4f7f\u7528\u7684\u8591\u9ec3\u7d20\u70baCurcumin C3 complex&nbsp;\u81a0\u56ca\u3002\u7d50\u679c\u767c\u73fe\u8591\u9ec3\u7d20\u7d44\u7684\u4e09\u9178\u7518\u6cb9\u916f\u3001\u4f4e\u5bc6\u5ea6\u81bd\u56fa\u9187\u53ca\u6975\u4f4e\u5bc6\u5ea6\u81bd\u56fa\u9187\u4ecb\u5165\u5f8c\u90fd\u6bd4\u4ecb\u5165\u524d\u986f\u8457\u4e0b\u964d\u3002\uff08Ref 24\uff09\u00fc &nbsp;&nbsp;\u4e00\u7bc7\u96a8\u6a5f\u96d9\u76f2\u5be6\u9a57\u4ee5&nbsp;70&nbsp;\u4f4d\u6025\u6027\u51a0\u72c0\u52d5\u8108\u7d9c\u5408\u75c7\u60a3\u8005\u70ba\u53d7\u8a66\u8005\uff0c\u5206\u6210\u56db\u7d44\uff0c\u7b2c\u4e00\u7d44\u651d\u53d6\u5b89\u6170\u5291\u3001\u7b2c\u4e8c\u3001\u4e09\u3001\u56db\u7d44\u6bcf\u5929\u5206\u5225\u651d\u53d6&nbsp;45mg\u300190mg\u3001180mg&nbsp;\u8591\u9ec3\u7d20\uff0c\u9032\u884c\u70ba\u671f&nbsp;2&nbsp;\u500b\u6708\u7684\u4ecb\u5165\u3002\u7d50\u679c\u767c\u73fe\u4ee5\u8591\u9ec3\u7d20\u4ecb\u5165\u4e4b\u5f8c\uff0c\u4e0d\u7ba1\u662f\u5728\u81bd\u56fa\u9187\u3001\u4f4e\u5bc6\u5ea6\u81bd\u56fa\u9187\u3001\u9ad8\u5bc6\u5ea6\u81bd\u56fa\u9187\u4ee5\u53ca\u4e09\u9178\u7518\u6cb9\u916f\uff0c\u8207\u4ecb\u5165\u524d\u90fd\u6c92\u6709\u986f\u8457\u5dee\u7570\u3002\uff08Ref 25\uff09\u00fc &nbsp;&nbsp;\u4e00\u7bc7\u8f03\u4e45\u4ee5\u524d\u7684\u7814\u7a76\uff0c\u8b93&nbsp;10&nbsp;\u4f4d\u5065\u5eb7\u53d7\u8a66\u8005\u651d\u53d6&nbsp;500mg&nbsp;\u7684\u8591\u9ec3\u7d20\u81a0\u56ca\uff0c\u4ecb\u5165\u6642\u9593\u70ba&nbsp;7&nbsp;\u5929\u3002\u7d50\u679c\u767c\u73fe\u8840\u6e05\u8102\u8cea\u904e\u6c27\u5316\u7269\u986f\u8457\u4e0b\u964d&nbsp;33%\u3001\u7e3d\u81bd\u56fa\u9187\u986f\u8457\u4e0b\u964d&nbsp;11.63%\u3001\u9ad8\u5bc6\u5ea6\u81bd\u56fa\u9187\u5247\u986f\u8457\u63d0\u5347&nbsp;29%\u3002\uff08Ref 26\uff09\u7d9c\u5408\u4ee5\u4e0a\u4e09\u7bc7\u7814\u7a76\u7d50\u679c\u800c\u8ad6\uff0c\u8591\u9ec3\u7d20\u5c0d\u65bc\u8840\u8102\u80aa\u7684\u4e0b\u964d\u6548\u679c\u6216\u8a31\u8207\u5291\u91cf\u6709\u95dc\uff0c\u8f03\u4f4e\u5291\u91cf\u7684\u8591\u9ec3\u7d20\u7121\u6cd5\u6709\u6548\u6539\u5584\u8840\u4e2d\u7684\u81bd\u56fa\u9187\u6216\u4e09\u9178\u7518\u6cb9\u916f\uff0c\u56e0\u6b64\u60f3\u55ae\u7d14\u9760\u98df\u7269\u6216\u8591\u9ec3\u7c89\u4f86\u6539\u5584\u662f\u4e0d\u592a\u53ef\u80fd\u7684\u3002&nbsp;\u67e5\u770b\u5176\u4ed6\u53ef\u80fd\u529f\u6548&nbsp; 5. \u9810\u9632\u7cd6\u5c3f\u75c5\u7814\u7a76\u767c\u73fe\uff0c\u8591\u9ec3\u7d20\u53ef\u4ee5\u6e1b\u5c11\u809d\u81df\u7684\u8461\u8404\u7cd6\u751f\u6210\uff0c\u6291\u5236\u9ad8\u8840\u7cd6\u5f15\u8d77\u7684\u767c\u708e\u53cd\u61c9\uff0c\u589e\u52a0\u7279\u5b9a\u57fa\u56e0\u8868\u73fe\u9032\u800c\u589e\u52a0\u7d30\u80de\u6c72\u53d6\u8461\u8404\u7cd6\uff0c\u56e0\u6b64\u53ef\u4ee5\u6e1b\u5c11\u80f0\u5cf6\u7d20\u62ee\u6297\u4e26\u964d\u4f4e\u8840\u7cd6\u3002\u65e9\u5728&nbsp;1972&nbsp;\u5e74\uff0c\u5c31\u6709\u7b2c\u4e00\u7bc7\u4eba\u9ad4\u5be6\u9a57\u767c\u73fe\u8591\u9ec3\u7d20\u5177\u6709\u964d\u8840\u7cd6\u7684\u6f5b\u529b\u3002\u9664\u4e86\u7cd6\u5c3f\u75c5\u672c\u8eab\uff0c\u7cd6\u5c3f\u75c5\u7684\u4f75\u767c\u75c7\uff08\u5305\u62ec\u814e\u75c5\u8b8a\u4ee5\u53ca\u8840\u7ba1\u75c5\u8b8a\uff09\u4e5f\u662f\u76ee\u524d\u5168\u7403\u5404\u570b\u9762\u81e8\u7684\u5065\u5eb7\u554f\u984c\uff0c\u5360\u4e86\u5168\u4e16\u754c\u91ab\u7642\u6d88\u8017\u7684\u5f88\u5927\u4e00\u90e8\u4efd\uff0c\u800c\u56e0\u70ba\u7cd6\u5c3f\u75c5\u800c\u6b7b\u4ea1\u7684\u6848\u4f8b\u4e3b\u8981\u4e5f\u90fd\u662f\u7531\u4f75\u767c\u75c7\u5c0e\u81f4\u3002 \u00fc &nbsp;&nbsp;\u4e00\u7bc7\u7814\u7a76\u4ee5&nbsp;14&nbsp;\u4f4d\u5065\u5eb7\u4eba\u70ba\u53d7\u8a66\u8005\u9032\u884c\u53e3\u670d\u8461\u8404\u7cd6\u8010\u53d7\u5ea6\u8a66\u9a57\uff08OGTT\u300175g\/250mL\uff09\uff0c\u5728\u559d\u7cd6\u6c34\u524d\u5148\u651d\u53d6\u5b89\u6170\u5291\u6216\u8591\u9ec3\u7d20\uff0c\u5b89\u6170\u5291\u70ba&nbsp;560mg&nbsp;\u4e73\u7cd6\uff0c\u5be6\u9a57\u7d44\u5247\u651d\u53d6&nbsp;170mg&nbsp;\u4e73\u7cd6\u53ca&nbsp;400mg&nbsp;\u8591\u9ec3\u7d20\uff0c\u7d50\u679c\u767c\u73fe\u559d\u7cd6\u6c34\u4e4b\u5f8c\u7684\u8840\u7cd6\u4ee5\u53ca\u5347\u7cd6\u6307\u6578\u5728\u5404\u6642\u9593\u9ede\u5747\u6c92\u6709\u986f\u8457\u5dee\u7570\uff0c\u800c\u651d\u53d6&nbsp;6g&nbsp;\u8591\u9ec3\u7d20\u7684\u53d7\u8a66\u8005\uff0c\u5728\u559d\u7cd6\u6c34\u5f8c&nbsp;30&nbsp;\u5206\u9418\u3001&nbsp;60&nbsp;\u5206\u9418\u8840\u6e05\u4e2d\u7684\u80f0\u5cf6\u7d20\uff0c\u4ee5\u53ca&nbsp;90&nbsp;\u5206\u9418\u5f8c\u7684\u80f0\u5cf6\u7d20\u6307\u6578\uff08insulinemic index\uff09\u5247\u662f\u6709\u986f\u8457\u63d0\u5347\uff0c\u89e3\u91cb\u4e86\u8591\u9ec3\u7d20\u5c0d\u65bc\u5065\u5eb7\u4eba\u53ef\u80fd\u6709\u4fc3\u9032\u80f0\u5cf6\u7d20\u5206\u6ccc\u7684\u6548\u679c\u3002\uff08Ref 27\uff09\u00fc &nbsp;&nbsp;\u4e00\u7bc7\u5927\u578b\u7684\u96a8\u6a5f\u96d9\u76f2\u5be6\u9a57\u4ee5&nbsp;240&nbsp;\u4f4d\u7cd6\u5c3f\u75c5\u524d\u671f\u60a3\u8005\u70ba\u53d7\u8a66\u8005\uff0c\u5206\u6210\u63a7\u5236\u7d44\u53ca\u5be6\u9a57\u7d44\u9032\u884c\u70ba\u671f&nbsp;9&nbsp;\u500b\u6708\u7684\u4ecb\u5165\uff0c\u6bcf\u5929\u5206\u5169\u6b21\u651d\u53d6\u516d\u9846\u5b89\u6170\u5291\u6216\u8591\u9ec3\u7d20\u81a0\u56ca\u3002\u672c\u7bc7\u7814\u7a76\u7684\u4f7f\u7528\u7684\u8591\u9ec3\u81a0\u56ca\u662f\u4ee5\u8591\u9ec3\u6839\u90e8\u78e8\u7c89\uff0c\u4e59\u9187\u8403\u53d6\uff0c\u6700\u7d42\u6bcf\u9846\u81a0\u56ca\u5927\u7d04\u542b\u6709&nbsp;250mg&nbsp;\u7684\u985e\u8591\u9ec3\u7d20\uff0c\u56e0\u6b64\u5be6\u9a57\u7d44\u7684\u8591\u9ec3\u7d20\u5291\u91cf\u7d04\u70ba&nbsp;1500mg\u3002\u7d50\u679c\u767c\u73fe\u4ecb\u5165\u5f8c\u7684&nbsp;3\u30016\u30019&nbsp;\u500b\u6708\u5be6\u9a57\u7d44\u7684\u7a7a\u8179\u8840\u7cd6\u3001\u7cd6\u5316\u8840\u8272\u7d20\u3001\u53e3\u670d\u8461\u8404\u7cd6\u8010\u53d7\u6027\u8a66\u9a57\u7684\u5e73\u5747\u503c\u90fd\u986f\u8457\u4f4e\u65bc\u63a7\u5236\u7d44\uff1b\u5be6\u9a57\u7d44\u8840\u6e05\u4e2d\u7684&nbsp;HOMA-b&nbsp;\u5230\u4e86\u7b2c&nbsp;9&nbsp;\u500b\u6708\u4e4b\u5f8c\u986f\u8457\u5730\u6bd4\u63a7\u5236\u7d44\u9ad8\u3001C-peptide&nbsp;\u5247\u986f\u8457\u6bd4\u63a7\u5236\u7d44\u4f4e\uff1b\u81e8\u5e8a\u4e0a\u53ef\u4ee3\u8868\u80f0\u5cf6\u7d20\u6297\u6027\u7684&nbsp;HOMA-IR&nbsp;\u5728\u4ecb\u5165\u5f8c\u7684&nbsp;3\u30016\u30019&nbsp;\u500b\u6708\u5be6\u9a57\u7d20\u7d44\u90fd\u986f\u8457\u5730\u6bd4\u63a7\u5236\u7d44\u4f4e\uff1b\u8102\u806f\u7d20\uff08adiponectin\uff09\uff0c\u4e00\u7a2e\u6297\u767c\u708e\u7684\u7d30\u80de\u6fc0\u7d20\uff0c\u63a7\u5236\u7d44\u5728\u4ecb\u5165\u524d\u5f8c\u6c92\u6709\u592a\u5927\u8b8a\u5316\uff0c\u5be6\u9a57\u7d44\u5247\u662f\u5728\u4ecb\u5165\u5f8c\u7b2c&nbsp;3\u30016&nbsp;\u500b\u6708\u90fd\u6709\u4e0a\u5347\uff0c\u76f4\u5230\u7b2c&nbsp;9&nbsp;\u500b\u6708\u8102\u806f\u7d20\u7684\u6fc3\u5ea6\u986f\u8457\u7684\u6bd4\u63a7\u5236\u7d44\u9ad8\uff1b\u6700\u7d42\uff0c\u63a7\u5236\u7d44\u7684\u53d7\u8a66\u8005\u5728\u7b2c&nbsp;6\u30019\u300112&nbsp;\u500b\u6708\u5206\u5225\u6709&nbsp;11&nbsp;\u4f4d\u300118&nbsp;\u4f4d\u53ca&nbsp;19&nbsp;\u4f4d\u9032\u5c55\u70ba\u7cd6\u5c3f\u75c5\uff0c\u5be6\u9a57\u7d44\u5247\u6c92\u6709\u4efb\u4f55\u4e00\u4f4d\u53d7\u8a66\u8005\u9032\u5c55\u70ba\u7cd6\u5c3f\u75c5\u3002\uff08Ref 28\uff09\u7d9c\u5408\u4ee5\u4e0a\u7814\u7a76\uff0c\u5728\u6975\u9ad8\u6fc3\u5ea6\u7684\u8591\u9ec3\u7d20\u651d\u53d6\u4e0b\uff0c\u53ef\u80fd\u6709\u63a7\u5236\u8840\u7cd6\u7684\u6548\u679c\u3002\u4f46\u4f4e\u6fc3\u5ea6\u662f\u5426\u4ecd\u6709\u6548\u679c\u672a\u77e5\uff0c\u53e6\u5916\u6b64\u7814\u7a76\u9032\u884c\u4e5d\u500b\u6708\uff0c\u7f3a\u4e4f\u9577\u671f\u7684\u8ffd\u8e64\uff0c\u56e0\u6b64\u9ad8\u6fc3\u5ea6\u8591\u9ec3\u7d20\u9577\u671f\u651d\u53d6\u7684\u5b89\u5168\u6027\u672a\u77e5\u3002&nbsp;\u67e5\u770b\u5176\u4ed6\u53ef\u80fd\u529f\u6548&nbsp; 6. \u7cd6\u5c3f\u75c5\u814e\u75c5\u8b8a\u00fc &nbsp;&nbsp;\u4e00\u7bc7\u96a8\u6a5f\u96d9\u76f2\u5be6\u9a57\u4ee5&nbsp;40&nbsp;\u4f4d\u6709\u7cd6\u5c3f\u75c5\u814e\u75c5\u8b8a\u7684\u60a3\u8005\u70ba\u53d7\u8a66\u8005\uff0c\u5206\u6210\u63a7\u5236\u7d44\u53ca\u5be6\u9a57\u7d44\uff0c\u9032\u884c\u70ba\u671f&nbsp;2&nbsp;\u500b\u6708\u7684\u4ecb\u5165\uff0c\u5176\u4e2d\u5be6\u9a57\u7d44\u6bcf\u5929\u651d\u53d6&nbsp;3&nbsp;\u6b21&nbsp;500mg&nbsp;\u7684\u8591\u9ec3\u81a0\u56ca\uff0c\u6bcf\u9320\u4e2d\u7d04\u6709&nbsp;22.1mg&nbsp;\u8591\u9ec3\u7d20\uff1b\u63a7\u5236\u7d44\u5247\u651d\u53d6\u5916\u89c0\u8207\u5be6\u9a57\u7d44\u76f8\u540c\u7684\u5b89\u6170\u5291\u3002\u7d50\u679c\u767c\u73fe\u8207\u4ecb\u5165\u524d\u76f8\u6bd4\uff0c\u5be6\u9a57\u7d44\u5c3f\u6db2\u4e2d\u7684&nbsp;IL-8&nbsp;\u4ee5\u53ca\u86cb\u767d\u8cea\u3001\u8840\u6e05\u4e2d\u7684&nbsp;TGF-b&nbsp;\u4ee5\u53ca&nbsp;IL-8&nbsp;\u90fd\u6709\u986f\u8457\u4e0b\u964d\u3002\uff08Ref 29\uff09\u5728\u77ed\u671f\u9593\u4f7f\u7528\u9ad8\u6fc3\u5ea6\u8591\u9ec3\u7d20\uff0c\u5c0d\u65bc\u7cd6\u5c3f\u75c5\u814e\u75c5\u8b8a\u7684\u63a7\u5236\u53ef\u80fd\u6709\u5e6b\u52a9\u3002&nbsp;\u67e5\u770b\u5176\u4ed6\u53ef\u80fd\u529f\u6548&nbsp; 7. \u7cd6\u5c3f\u75c5\u5fae\u8840\u7ba1\u75c5\u8b8a\u00fc &nbsp;&nbsp;\u4e00\u7bc7\u7814\u7a76\u4ee5\u6c92\u6709\u300c\u52d5\u8108\u7ca5\u72c0\u786c\u5316\u300d\u6216\u300c\u5fc3\u8840\u7ba1\u75be\u75c5\u98a8\u96aa\u56e0\u5b50\u300d\u7684\u7cd6\u5c3f\u75c5\u60a3\u8005\u70ba\u53d7\u8a66\u8005\uff0c\u5be6\u9a57\u7d44\u4e00\u5929\u651d\u53d6&nbsp;2&nbsp;\u6b21&nbsp;Meriva\uff08\u4e00\u7a2e\u8591\u9ec3\u7d20\u8207\u78f7\u8102\u91af\u81bd\u9e7c\u8907\u5408\u7684\u7522\u54c1\uff09\uff0c\u6bcf\u5929\u5291\u91cf\u70ba&nbsp;1g\uff0c\u4ecb\u5165\u6642\u9593\u70ba&nbsp;4&nbsp;\u9031\u3002\u7d50\u679c\u767c\u73fe\u4ecb\u5165\u4e4b\u5f8c\u76ae\u819a\u8868\u9762\u7684\u4f11\u606f\u8840\u6d41\u91cf\u6709\u986f\u8457\u6e1b\u5c11\u7684\u60c5\u6cc1\uff0c\u4e00\u822c\u7cd6\u5c3f\u75c5\u5fae\u8840\u7ba1\u75c5\u8b8a\u7684\u60a3\u8005\u8840\u6d41\u91cf\u90fd\u6703\u589e\u52a0\uff0c\u89e3\u91cb\u8591\u9ec3\u7d20\u5c0d\u65bc\u5fae\u8840\u7ba1\u75c5\u8b8a\u53ef\u80fd\u6709\u6539\u5584\u7684\u6548\u679c\uff1b\u53e6\u5916\u4e5f\u89c0\u5bdf\u5230\u6c34\u816b\u72c0\u6cc1\u986f\u8457\u6539\u5584\uff1b\u975c\u8108\u2014\u52d5\u8108\u53cd\u61c9\uff08venoarteriolar response\uff09\u986f\u8457\u63d0\u5347\uff1bPO2&nbsp;\u4e0a\u5347\u7684\u60c5\u5f62\uff0c\u4f5c\u8005\u63a8\u6e2c\u53ef\u80fd\u662f\u7531\u65bc\u6c27\u6c23\u64f4\u6563\u5230\u76ae\u819a\u7684\u72c0\u6cc1\u8f03\u597d\uff0c\u4e14\u6c34\u816b\u6539\u5584\u7684\u7de3\u6545\u3002\uff08Ref 30\uff09\u76ee\u524d\u7684\u7814\u7a76\u986f\u793a\u8591\u9ec3\u5c0d\u7cd6\u5c3f\u75c5\u70ba\u8840\u7ba1\u75c5\u8b8a\u53ef\u80fd\u6709\u5e6b\u52a9\uff0c\u4f46\u6a5f\u5236\u4e0d\u660e\u78ba\u3002&nbsp;\u67e5\u770b\u5176\u4ed6\u53ef\u80fd\u529f\u6548&nbsp; 8. \u80a5\u80d6\u8591\u9ec3\u7d20\u53ef\u4ee5\u6291\u5236\u7d72\u88c2\u539f\u6d3b\u5316\u86cb\u767d\u6fc0\u9176\uff08MAPK, ERK, JNK, and p38\uff09\uff0c\u800c\u9019\u4e9b\u6fc0\u9176\u8207&nbsp;3T3-L1&nbsp;\u7d30\u80de\u682a\u5206\u5316\u6210\u70ba\u8102\u80aa\u7d30\u80de\u76f8\u95dc\uff0c\u5728\u5df2\u5206\u5316\u7684\u8102\u80aa\u7d30\u80de\u4e2d\u4e5f\u6703\u6d3b\u5316&nbsp;Wnt\/\u03b2-catenin&nbsp;\u7684\u50b3\u5c0e\u9014\u5f91\u2014\u2014\u800c\u9019\u4e9b\u90fd\u8207\u80a5\u80d6\u5bc6\u4e0d\u53ef\u5206\u3002\u5728\u767d\u8272\u8102\u80aa\u7d44\u7e54\u4e2d\uff0c\u8591\u9ec3\u7d20\u53ef\u4ee5\u6e1b\u5c11\u5de8\u566c\u7d30\u80de\u6d78\u6f64\u3001\u7626\u9ad4\u7d20\uff1b\u5728\u767c\u708e\u76f8\u95dc\u7684\u80a5\u80d6\uff0c\u8591\u9ec3\u7d20\u53ef\u4ee5\u7a31\u52a0\u8102\u806f\u7d20\uff08Adeponectin\uff09\u7684\u8868\u73fe\uff0c\u6291\u5236&nbsp;NF-kB&nbsp;\u7684\u6d3b\u6027\uff0c\u56e0\u6b64\u63a8\u6e2c\u5c0d\u65bc\u80a5\u80d6\u6709\u6291\u5236\u7684\u6548\u679c\uff08Ref 1\uff09\uff0c\u4f46\u4ecd\u9700\u4eba\u9ad4\u8a66\u9a57\u4f86\u8b49\u5be6\u3002\u8591\u9ec3\u5c0d\u65bc\u5df2\u77e5\u8207\u80a5\u80d6\u76f8\u95dc\u7684\u9175\u7d20\u6291\u5236\u6216\u6d3b\u5316\u6709\u95dc\uff0c\u7406\u8ad6\u4e0a\u53ef\u80fd\u5c0d\u65bc\u80a5\u80d6\u6709\u6291\u5236\u6548\u679c\u3002\u4f46\u9019\u4e9b\u7814\u7a76\u8ddd\u96e2\u4eba\u9ad4\u8a66\u9a57\u9084\u6709\u5f88\u5927\u8ddd\u96e2\uff0c\u53e6\u5916\u80a5\u80d6\u662f\u591a\u91cd\u56e0\u7d20\u5f71\u97ff\uff0c\u60f3\u8981\u9760\u8591\u9ec3\u6e1b\u91cd\u7684\u8a71\u73fe\u968e\u6bb5\u9084\u662f\u5148\u5225\u5984\u60f3\u3002&nbsp;\u67e5\u770b\u5176\u4ed6\u53ef\u80fd\u529f\u6548&nbsp; 9. \u514b\u9686\u6c0f\u75c7\uff08Crohn\u2019s disease\uff09\u56e0\u514d\u75ab\u53d7\u640d\u5c0e\u81f4\u7684\u767c\u708e\u6027\u8178\u9053\u75be\u75c5\u4e3b\u8981\u5305\u62ec\u514b\u9686\u6c0f\u75c7\uff08Crohn\u2019s disease\uff09\u4ee5\u53ca\u6f70\u760d\u6027\u5927\u8178\u708e\uff08ulcerative colitis\uff09\uff0c\u5e38\u898b\u7684\u8868\u73fe\u65b9\u5f0f\u5c31\u662f\u6d88\u5316\u7cfb\u7d71\u7684\u6162\u6027\u767c\u708e\u3002\u8591\u9ec3\u7d20\u53ef\u900f\u904e\u8a31\u591a\u50b3\u5c0e\u9014\u5f91\u4f86\u8abf\u7bc0\u767c\u708e\u53cd\u61c9\uff0c\u56e0\u6b64\u63a8\u6e2c\u5c0d\u65bc\u767c\u708e\u6027\u8178\u9053\u75be\u75c5\u5c31\u6709\u4fdd\u8b77\u7684\u6548\u679c\u3002\u00fc &nbsp;&nbsp;\u4e00\u7bc7\u524d\u77bb\u6027\u7684\u958b\u653e\u6a19\u7c64\u7814\u7a76\uff0c\u4ee5&nbsp;5&nbsp;\u4f4d\u6709\u514b\u9686\u6c0f\u75c7\u7684\u60a3\u8005\u4f5c\u70ba\u53d7\u8a66\u8005\uff0c\u9023\u7e8c&nbsp;1&nbsp;\u500b\u6708\u6bcf\u5929\u651d\u53d6\u5169\u6b21&nbsp;550mg&nbsp;\u8591\u9ec3\u7d20\uff0c\u4e4b\u5f8c&nbsp;1&nbsp;\u500b\u6708\u6bcf\u5929\u651d\u53d6\u4e09\u6b21\uff0c\u4e26\u4ee5&nbsp;Crohn\u2019s Disease 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